Methyl 4-[(1,3-dihydroxypropan-2-yl)oxy]butanoate | 820247-03-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: Methyl 4-[(1,3-dihydroxypropan-2-yl)oxy]butanoate
• 英文别名: methyl 4-(1,3-dihydroxypropan-2-yloxy)butanoate
• CAS: 820247-03-8
• 化学式: C₈H₁₆O₅
• 分子量: 192.212
• InChiKey: WOSQFSKPNBVTKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N'-二琥珀酰亚胺基碳酸酯 、 Methyl 4-[(1,3-dihydroxypropan-2-yl)oxy]butanoate 在 吡啶 作用下， 以 乙腈 为溶剂， 以2.8 g的产率得到Methyl 4-[1,3-bis[(2,5-dioxopyrrolidin-1-yl)oxycarbonyloxy]propan-2-yloxy]butanoate
  参考文献：
  名称：

  Compositions Comprising a Polymeric Reagent and a Pharmacologically Active Agent

  摘要：

  提供了共轭物的制药组合物。这些共轭物可以通过将具有特定原子排列的聚合物试剂与药理活性试剂共轭而制备。还提供了相关的方法、制备等。

  公开号：

  US20150328331A1
• 作为产物：
  描述：

  [3-Hydroxy-2-(hydroxymethyl)-2-methylpropyl] 4-[(2-phenyl-1,3-dioxan-5-yl)oxy]butanoate 在 硫酸 、 水 、 sodium hydroxide 作用下， 以 水 、 乙腈 为溶剂， 反应 9.5h， 生成 Methyl 4-[(1,3-dihydroxypropan-2-yl)oxy]butanoate
  参考文献：
  名称：

  Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom

  摘要：

  本发明提供了适用于与生物活性剂反应形成共轭物的聚合物试剂，其中聚合物试剂包括一种或多种聚合物链和多种羟基磷灰石靶向基团，可选地，试剂包括一种或多种可降解的连接，用于将聚合物链分割成具有适合肾脏清除的分子量的聚合物段。

  公开号：

  US09173947B2

文献信息

• PEG derivatives containing two PEG chains
  申请人：Nektar Therapeutics

  公开号：EP2644206A2

  公开（公告）日：2013-10-02

  Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.

  聚合物试剂由按特定顺序排列的原子分子组成，其中原子分子位于水溶性聚合物和活性基团之间。这些聚合物试剂主要用于形成聚合物-活性剂共轭物。还提供了相关的方法、组合物、制剂等。
• Polymer derivatives having particular atom arrangements
  申请人：Nektar Therapeutics

  公开号：US10646578B2

  公开（公告）日：2020-05-12

  Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.

  聚合物试剂由按特定顺序排列的原子分子组成，其中原子分子位于水溶性聚合物和活性基团之间。这些聚合物试剂主要用于形成聚合物-活性剂共轭物。还提供了相关的方法、组合物、制剂等。
• Hydroxyapatite-Targeting Multiarm Polymers and Conjugates Made Therefrom
  申请人：McManus Samuel P.

  公开号：US20100286355A1

  公开（公告）日：2010-11-11

  The present invention provides hydmoxyapatite-targeting, multiarm polymer reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains and a plurality of hydroxyapatile-targeting moieties located at the terminus of one or more of the polymer chains. The multiarm polymers are optionally divided or separated by one or more degradable linkages into polymer segments having a molecular weight suitable for renal clearance. The polymeric reagents of the invention can have a substantially linear structure, although branched or multiarm structures are contemplated as well. The invention is suited for applications in which use of a high molecular weight polymer is desired, such as a total polymer number average molecular weight of at least about 30,000 Da for linear polymers and 20,000 Da for multiarm polymers. Each structure includes one or more linkages capable of degradation in vivo. The use of multiple hydroxyapatite-targeting moieties on each polymer molecule enhances the ability of the polymer reagent to selectively target and bind to hydroxyapatite surfaces, which in turn, can increase the concencentration of biologically active moiety delivered to the bone site.
• Methods for Forming Polymer-Drug Conjugates
  申请人：Harris J. Milton

  公开号：US20110178242A1

  公开（公告）日：2011-07-21

  Methods for preparing polymer-drug conjugates are provided. The disclosed methods involve polymeric reagents comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. Related methods, compositions, preparations, and so forth are also provided.
• Segmented Degradable Polymers and Conjugates Made Therefrom
  申请人：Nektar Therapeutics

  公开号：US20130072709A1

  公开（公告）日：2013-03-21

  The present invention provides, among other things, segmented, degradable polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains divided or separated by one or more degradable linkages into polymer segments having a molecular weight suitable for renal clearance. The polymeric reagents can have a substantially linear structure, a branched structure, or a multiarm structure. Each structure includes one or more linkages capable of degradation in vivo.