bis(8-(N-succinimidyloxycarbonyloxy)-3,6-dioxaoctyl)disulfide | 214278-27-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: bis(8-(N-succinimidyloxycarbonyloxy)-3,6-dioxaoctyl)disulfide
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 2-[2-[2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxycarbonyloxyethoxy]ethoxy]ethyldisulfanyl]ethoxy]ethoxy]ethyl carbonate
• CAS: 214278-27-0
• 化学式: C₂₂H₃₂N₂O₁₄S₂
• 分子量: 612.633
• InChiKey: CVGOQCRMZDARFR-UHFFFAOYSA-N

物化性质

• 沸点：
  687.256±65.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.453±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.87
• 重原子数：
  40.0
• 可旋转键数：
  21.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  182.74
• 氢给体数：
  0.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  1,2-二肉豆蔻酰基磷脂酰乙醇胺 、 bis(8-(N-succinimidyloxycarbonyloxy)-3,6-dioxaoctyl)disulfide 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 2.0h， 以85%的产率得到bis-(8-(L-α-dimyristoylphosphatidylethanolaminocarbonyloxy)-3,6-dioxaoctyl)disulfide
  参考文献：
  名称：

  N,N′-Disuccinimidyl carbonate as a coupling agent in the synthesis of thiophospholipids used for anchoring biomembranes to gold surfaces

  摘要：

  N,N'-Disuccinimidyl carbonate has been used to couple diacylglycerophosphatidylethanolamine with bis-omega-hydroxypolyethylenoxydisulfide. The resultant thiophospholipids can be used for anchoring biomembranes to gold surfaces. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00674-7
• 作为产物：
  描述：

  3,6-二噁-8-疏基辛烷-1-醇 在 碘 、 potassium carbonate 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 6.0h， 生成 bis(8-(N-succinimidyloxycarbonyloxy)-3,6-dioxaoctyl)disulfide
  参考文献：
  名称：

  N,N′-Disuccinimidyl carbonate as a coupling agent in the synthesis of thiophospholipids used for anchoring biomembranes to gold surfaces

  摘要：

  N,N'-Disuccinimidyl carbonate has been used to couple diacylglycerophosphatidylethanolamine with bis-omega-hydroxypolyethylenoxydisulfide. The resultant thiophospholipids can be used for anchoring biomembranes to gold surfaces. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00674-7

文献信息

• N,N′-Disuccinimidyl carbonate as a coupling agent in the synthesis of thiophospholipids used for anchoring biomembranes to gold surfaces
  作者：Neville Boden、Richard J. Bushby、Quanying Liu、Stephen D. Evans、A.Toby A. Jenkins、Peter F. Knowles、Robert E. Miles

  DOI：10.1016/s0040-4020(98)00674-7

  日期：1998.9

  N,N'-Disuccinimidyl carbonate has been used to couple diacylglycerophosphatidylethanolamine with bis-omega-hydroxypolyethylenoxydisulfide. The resultant thiophospholipids can be used for anchoring biomembranes to gold surfaces. (C) 1998 Elsevier Science Ltd. All rights reserved.