3-Hydroxy-N-methylmorphinan phosphate,(-)- | 63690-39-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 3-Hydroxy-N-methylmorphinan phosphate,(-)-
• 英文别名: (1R,9R,10R)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol;phosphoric acid
• CAS: 63690-39-1
• 化学式: C17H26NO5P
• 分子量: 355.4
• InChiKey: GHXBWQDBWRSARY-DYWKTHLTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.15
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  101
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Extended Release Oral Pharmaceutical Compositions of 3-Hydroxy-N-Methylmorphinan and Method of Use
  申请人：Babul Najib

  公开号：US20120065221A1

  公开（公告）日：2012-03-15

  The present invention is directed to oral, therapeutically effective extended release pharmaceutical compositions of 3-hydroxy-N-methylmorphinan, including delayed onset, extended release dosage forms and the use thereof.

  本发明涉及口服、治疗有效的3-羟基-N-甲基吗啡酮的延迟作用、延长释放药物组成物，包括延迟起效、延长释放剂型及其使用。
• EXTENDED RELEASE ORAL PHARMACEUTICAL COMPOSITIONS OF 3-HYDROXY-N-METHYLMORPHINAN AND METHOD OF USE
  申请人：Relmada Therapeutics, Inc.

  公开号：EP2448406B1

  公开（公告）日：2016-04-20
• [EN] EXTENDED RELEASE ORAL PHARMACEUTICAL COMPOSITIONS OF 3-HYDROXY-N-METHYLMORPHINAN AND METHOD OF USE<br/>[FR] COMPOSITIONS PHARMACEUTIQUES ORALES À LIBÉRATION PROLONGÉE DE 3-HYDROXY-N-MÉTHYLMORPHINANE ET PROCÉDÉ D'UTILISATION
  申请人：THERAQUEST BIOSCIENCES INC

  公开号：WO2010099508A1

  公开（公告）日：2010-09-02

  The present invention is directed to oral, therapeutically effective extended release pharmaceutical compositions of 3-hydroxy-N-methylmorphinan, including delayed onset, extended release dosage forms and the use thereof.