4-(6-Methoxybenzo[b]thiophen-2-yl)-1,2,5,6-tetrahydropyridine | 346696-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 4-(6-Methoxybenzo[b]thiophen-2-yl)-1,2,5,6-tetrahydropyridine
• 英文别名: 4-(6-methoxy-1-benzothiophen-2-yl)-1,2,3,6-tetrahydropyridine
• CAS: 346696-26-2
• 化学式: C₁₄H₁₅NOS
• 分子量: 245.345
• InChiKey: RWQIYLMCHMRWBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  49.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(6-Methoxybenzo[b]thiophen-2-yl)-1,2,5,6-tetrahydropyridine 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 乙醇 、 2,2,2-三氟乙醇 为溶剂， 生成 (S)-1-(1H-Indol-4-yloxy)-3-[4-(6-methoxy-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol
  参考文献：
  名称：

  Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1

  摘要：

  A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. 1-(4H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high affinity at the 5-HT1A receptor and serotonin reuptake inhibition at nanomolar concentrations for dual activities. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00303-2
• 作为产物：
  描述：

  6-甲氧基苯并噻吩 在 正丁基锂 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 4-(6-Methoxybenzo[b]thiophen-2-yl)-1,2,5,6-tetrahydropyridine
  参考文献：
  名称：

  Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1

  摘要：

  A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. 1-(4H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high affinity at the 5-HT1A receptor and serotonin reuptake inhibition at nanomolar concentrations for dual activities. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00303-2

文献信息

• Benzofuran derivatives
  申请人：——

  公开号：US20030232833A1

  公开（公告）日：2003-12-18

  The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine. 1

  本发明提供了一种化合物，其化学式为（I），可用于治疗抑郁症、焦虑症，并缓解因戒烟或部分戒烟引起的症状。
• Method of manufacturing liposomes
  申请人：——

  公开号：US20020001613A1

  公开（公告）日：2002-01-03

  The present invention relates to a method of making a liposome, said method comprising the steps of: (a) mixing a lipophilic phase and a hydrophilic phase, said lipophilic phase comprising an amphiphilic bilayer-forming substance; and (b) applying a cavitational sheer force to said mixture to form said liposome; wherein said cavitational force is created by contacting said mixture with a member that vibrates at an ultrasonic frequency.

  本发明涉及一种制造脂质体的方法，所述方法包括以下步骤：(a) 混合亲脂相和亲水相，所述亲脂相包括两性双层形成物质；以及 (b) 对所述混合物施加空化剪切力以形成所述脂质体；其中，所述空化剪切力是通过将所述混合物与以超声波频率振动的部件接触而产生的。
• Liposomal encapsulation of glycosaminoglycans for the treatment of arthritic joints
  申请人：Thompson Jonathan

  公开号：US20050123593A1

  公开（公告）日：2005-06-09

  In a preferred embodiemnt the present invention features a composition and method of delivery comprising Glycosaminoglycans encapsulated in a liposomal delivery system for intraarticular administration for the treatment of osteoarthritis In a more preferred embodiemnt the present invention features a composition and method of delivery comprising hyaluronic acid encapsulated in a liposomal delivery system for intraarticular administration for the treatment of osteoarthritis.

  在一个优选的实施方案中，本发明具有一种组合物和给药方法，该组合物和给药方法包括包裹在脂质体给药系统中的糖胺聚糖，该脂质体给药系统用于关节内给药，以治疗骨关节炎。
• DUAL LOADED LIPOSOMAL PHARMACEUTICAL FORMULATIONS
  申请人：Cureport, Inc.

  公开号：EP3265063A1

  公开（公告）日：2018-01-10
• US6844344B2
  申请人：——

  公开号：US6844344B2

  公开（公告）日：2005-01-18