3-methoxythioxanthene | 127906-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻喃类
• 英文名称: 3-methoxythioxanthene
• 英文别名: 3-methoxy-9H-thioxanthene
• CAS: 127906-98-3
• 化学式: C₁₄H₁₂OS
• 分子量: 228.315
• InChiKey: VBICDGYLZYWATG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methoxythioxanthene 、 3-Hydroxy thioxanthene 、 氢溴酸 、 碘乙烷 、 potassium carbonate 以 溶剂黄146 为溶剂， 以to produce 3-ethoxythioxanthone 1 according to Scheme III的产率得到3-Ethoxythioxanthone
  参考文献：
  名称：

  1-Methyl-4- (3-ethoxy-9H-thioxanthene-9-ylidene) -piperidine and its use as 5-HT2B/H1 receptor antagonist

  摘要：

  本发明涉及1-甲基-4-(3-乙氧基-9H-噻吩并[9-ylidene]-哌啶及其药学上可接受的盐，以及将1-甲基-4-(3-乙氧基-9H-噻吩并[9-ylidene]-哌啶用作药物治疗可通过5-HT2B、H1或5-HT2B/H1受体拮抗剂治疗的疾病状态的制剂的制造方法。

  公开号：

  US20030022920A1
• 作为产物：
  描述：

  2-(3-Methoxyphenylthio)benzoyl chloride 在 sodium tetrahydroborate 、 三氯氧磷 作用下， 以 苯 为溶剂， 反应 57.0h， 生成 3-methoxythioxanthene
  参考文献：
  名称：

  Jilek, Jiri; Sindelar, Karel; Pomykacek, Josef, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 12, p. 3294 - 3338

  摘要：

  DOI：

文献信息

• Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament
  申请人：Biofrontera Pharmaceuticals AG

  公开号：EP1321169A1

  公开（公告）日：2003-06-25

  The present invention relates to the use of (S)-α-fluoromethylhistidine and esters and pharmaceutically acceptable salts thereof in combination with a serotonin receptor antagonist or a pharmaceutically acceptable salt thereof as a medicament and for the manufacture of a medicament for treatment of a disease state which can be alleviated by treatment with a serotonin receptor antagonist and/or a histamine receptor antagonist.

  本发明涉及使用(S)-α-氟甲基组氨酸及其酯和药学上可接受的盐与5-羟色胺受体拮抗剂或其药学上可接受的盐结合作为药物，并用于制造一种治疗可通过使用5-羟色胺受体拮抗剂和/或组胺受体拮抗剂进行缓解的疾病状态的药物。
• Derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
  申请人：——

  公开号：US20030166672A1

  公开（公告）日：2003-09-04

  The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament and for the manufacture of a medicament for treatment of a disease state which can be alleviated by treatment with a 5-HT2B antagonist.

  本发明涉及4-(硫或硒-9-亚甲基黄色素基)-哌啶或吖啶的衍生物及其药学上可接受的盐，这些化合物作为药物的使用，用于制造治疗可通过5-HT2B拮抗剂治疗缓解的疾病状态的药物。
• Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
  申请人：Biofrontera Pharmaceuticals AG

  公开号：EP1306376A1

  公开（公告）日：2003-05-02

  The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, according to the Formula use of these compounds as a medicament and for the manufacture of a medicament for treatment of a disease state which can be alleviated by treatment with a 5-HT2B antagonist.

  本发明涉及4-(硫或硒芴-9-亚基)-哌啶或吖啶的衍生物及其药学上可接受的盐，根据该式使用这些化合物作为药物治疗可以通过5-HT2B拮抗剂治疗缓解的疾病状态，并用于制造药物。
• DERIVATIVES OF 4-(THIO-OR SELENOXANTHENE-9-YLIDENE)-PIPERIDINE OR ACRIDINE AND ITS USE AS A SELECTIVE 5-HT2B RECEPTOR ANTAGONIST
  申请人：Lubbert Hermann

  公开号：US20060183905A1

  公开（公告）日：2006-08-17

  The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament and for the manufacture of a medicament for treatment of a disease state which can be alleviated by treatment with a 5-HT2B antagonist.

  本发明涉及4-（硫或硒萘茶酚-9-基亚甲基）-哌啶或吖啶的衍生物及其药学上可接受的盐，以及这些化合物作为药物的用途，用于制造用于治疗可以通过5-HT2B拮抗剂治疗缓解的疾病状态的药物。
• 1-methyl-4-(3-ethoxy-9h-thioxanthene-ylidene)-piperidine and its use as 5-HT2B and/or H1 antagonist
  申请人：Biofrontera Pharmaceuticals AG

  公开号：EP1270568A1

  公开（公告）日：2003-01-02

  The present invention relates to 1-methyl-4-(3-ethoxy-9H-thioxanthene-9-ylidene)-piperidine and pharmaceutically acceptable salts thereof, use of 1-methyl-4-(3-ethoxy-9H-thioxanthene-9-ylidene)-piperidine as a medicament and for the manufacture of a medicament for treatment of a disease state which is alleviable by treatment with a 5-HT2B or H1o or 5-HT2B/H1 receptor antagonists.

  本发明涉及1-甲基-4-(3-乙氧基-9H-噻噁蒽-9-亚基)-哌啶及其药学上可接受的盐、1-甲基-4-(3-乙氧基-9H-噻噁蒽-9-亚基)-哌啶作为药物的用途以及用于制造治疗可通过5-HT2B或H1o或5-HT2B/H1受体拮抗剂治疗而缓解的疾病状态的药物。