Cambridge id 5341535

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Cambridge id 5341535
• 英文别名: 4-[4-(3,4-dimethoxyphenyl)-6-phenylpyrimidin-2-yl]morpholine
• 化学式: C₂₂H₂₃N₃O₃
• 分子量: 377.4
• InChiKey: KMTWCUXXCYMLNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  56.7
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• HEPARAN SULFATE INHIBITORS
  申请人：Zacharon Pharmaceuticals, Inc.

  公开号：EP2307440A2

  公开（公告）日：2011-04-13
• [EN] HEPARAN SULFATE INHIBITORS<br/>[FR] INHIBITEURS D'HÉPARANE SULFATE
  申请人：ZACHARON PHARMACEUTICALS INC

  公开号：WO2010003023A2

  公开（公告）日：2010-01-07

  Provided herein are heparan sulfate inhibitors, including modulators of heparan sulfate glycosylation, heparan sulfate sulfation, and/or heparan sulfate epimerization.
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT ET DE PRÉVENTION DE TROUBLES NEUROLOGIQUES
  申请人：YUMANITY THERAPEUTICS INC

  公开号：WO2021252895A2

  公开（公告）日：2021-12-16

  The invention provides compositions and methods for treating neurological disorders, such as amyotrophic lateral sclerosis, frontotemporal degeneration, and Alzheimer's disease, among others. Using the compositions and methods described herein, a patient having a neurological disorder, such as a neurological disorder associated with TAR-DNA binding protein (TDP)-43 aggregation, may be administered an inhibitor of FYVE-type zinc finger containing phosphoinositide kinase (PIKfyve) so as to treat an underlying etiology of the disorder and/or to alleviate one or more symptoms of the disease. The inhibitor of PIKfyve may be a small molecule, an anti-PIKfyve antibody or antigen-binding fragment thereof, or a compound, such as an interfering RNA molecule, that attenuates PIKfyve expression. Patients that may be treated using the compositions and methods described herein include those that express are susceptible to developing TDP-43- mediated aggregation and toxicity.