1-benzyl-6-ethyl-5-methyl-3-(toluene-4-sulfonyl)pyridin-2-one | 952228-75-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyl-6-ethyl-5-methyl-3-(toluene-4-sulfonyl)pyridin-2-one
• 英文别名: 1-Benzyl-6-ethyl-5-methyl-3-(4-methylphenyl)sulfonylpyridin-2-one
• CAS: 952228-75-0
• 化学式: C₂₂H₂₃NO₃S
• 分子量: 381.496
• InChiKey: HLMJNDPSWVLTMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-benzyl-6-ethyl-5-methyl-3-(toluene-4-sulfonyl)pyridin-2-one 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 24.25h， 生成
  参考文献：
  名称：

  A facile approach to polysubstituted 2-pyridones. Application to the synthesis of 3,4-disubstituted isoquinolinone and total synthesis of oxyisoterihanine

  摘要：

  A facile approach to polysubstituted 2-pyridones from 1-benzyl- 5,6-dialkyl-3-(4-toluenesulfonyl) pyridin-2-one was described. A new approach to 3,4-disubstituted isoquinolinone and total synthesis of oxyisoterihanine will also be reported. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.06.101
• 作为产物：
  描述：

  乙基溴化镁 、 1-benzyl-3-(4-methylphenylsulfonyl)-5-methylpiperidine-2,6-dione 生成 1-benzyl-6-ethyl-5-methyl-3-(toluene-4-sulfonyl)pyridin-2-one
  参考文献：
  名称：

  A facile approach to polysubstituted 2-pyridones. Application to the synthesis of 3,4-disubstituted isoquinolinone and total synthesis of oxyisoterihanine

  摘要：

  A facile approach to polysubstituted 2-pyridones from 1-benzyl- 5,6-dialkyl-3-(4-toluenesulfonyl) pyridin-2-one was described. A new approach to 3,4-disubstituted isoquinolinone and total synthesis of oxyisoterihanine will also be reported. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.06.101

文献信息

• A facile approach to polysubstituted 2-pyridones. Application to the synthesis of 3,4-disubstituted isoquinolinone and total synthesis of oxyisoterihanine
  作者：Tsung-Hsiu Tsai、Wen-Hsuan Chung、Jung-Kai Chang、Ru-Ting Hsu、Nein-Chen Chang

  DOI：10.1016/j.tet.2007.06.101

  日期：2007.9

  A facile approach to polysubstituted 2-pyridones from 1-benzyl- 5,6-dialkyl-3-(4-toluenesulfonyl) pyridin-2-one was described. A new approach to 3,4-disubstituted isoquinolinone and total synthesis of oxyisoterihanine will also be reported. (C) 2007 Elsevier Ltd. All rights reserved.