[2-Methyl-4-(2-morpholin-4-ylethyl)imidazo[1,2-a]benzimidazol-1-yl]-thiophen-2-ylmethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: [2-Methyl-4-(2-morpholin-4-ylethyl)imidazo[1,2-a]benzimidazol-1-yl]-thiophen-2-ylmethanone
• 化学式: C₂₁H₂₂N₄O₂S
• 分子量: 394.5
• InChiKey: KWHCBVYCCCPFBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  80
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• SMALL MOLECULE INHIBITORS FOR MRP1 AND OTHER MULTIDRUG TRANSPORTERS
  申请人：THE CLEVELAND CLINIC FOUNDATION

  公开号：EP1753422B1

  公开（公告）日：2008-05-28
• Small Molecule Inhibitors of Mrp1 and Other Multidrug Transporters
  申请人：Gudkov Andrei

  公开号：US20080032966A1

  公开（公告）日：2008-02-07

  A method of potentiating the activity of a therapeutic drug, like a chemotherapeutic drug or an antibiotic, in a cell or tissue, by inhibiting the efflux capability of a multidrug transporter are disclosed. The method is useful in the treatment of a cancer by sensitizing tumor cells to a chemotherapeutic agent. Compounds capable of inhibiting an efflux capability of a multidrug transporter also are disclosed.
• US8318724B2
  申请人：——

  公开号：US8318724B2

  公开（公告）日：2012-11-27