N-(2-amino-3,5-dicyano-4-methylsulfanyl-6-oxopyridin-1-yl)benzenesulfonamide | 394234-97-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-amino-3,5-dicyano-4-methylsulfanyl-6-oxopyridin-1-yl)benzenesulfonamide
• CAS: 394234-97-0
• 化学式: C₁₄H₁₁N₅O₃S₂
• 分子量: 361.405
• InChiKey: LUNXPMFPZZQUFW-UHFFFAOYSA-N

物化性质

• 沸点：
  424.6±55.0 °C(Predicted)
• 密度：
  1.61±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  174
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N-(2-amino-3,5-dicyano-4-methylsulfanyl-6-oxopyridin-1-yl)benzenesulfonamide 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以75%的产率得到N-(3,6-diamino-7-cyano-4-oxo-1H-pyrazolo[4,3-c]pyridin-5-yl)benzenesulfonamide
  参考文献：
  名称：

  A NEW GENERAL METHOD FOR SUBSTITUTED 4-ALKYLTHIO-N-ARYLSULPHONYL-AMINO-2-PYRIDONES: REACTION OF KETENE-SS-ACETALS WITH ARYLSULPHONYLHYDRAZIDES

  摘要：

  A novel and efficient method for the synthesis of substituted 4-alkylthio-N-arylsulphonylamino-2-pyridones via the reaction of ketene-SS-acetals with N-cyanoacetoarylsulfonyl-hydrazides has been investigated. 1-Arylsulfonylamino-pyrazolo[3,4-c]pyridine-2(1H)-ones have also been prepared from the reaction of 4-alkylthio-N-arylsulfonylamino-2-pyridones with hydrazines.

  DOI：

  10.1080/10426500108040593
• 作为产物：
  描述：

  cyanoacetyl-N-phenylsulfonylhydrazide 、 [双(甲硫基)亚甲基]丙烷二腈 在 氢氧化钾 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以75%的产率得到N-(2-amino-3,5-dicyano-4-methylsulfanyl-6-oxopyridin-1-yl)benzenesulfonamide
  参考文献：
  名称：

  A NEW GENERAL METHOD FOR SUBSTITUTED 4-ALKYLTHIO-N-ARYLSULPHONYL-AMINO-2-PYRIDONES: REACTION OF KETENE-SS-ACETALS WITH ARYLSULPHONYLHYDRAZIDES

  摘要：

  A novel and efficient method for the synthesis of substituted 4-alkylthio-N-arylsulphonylamino-2-pyridones via the reaction of ketene-SS-acetals with N-cyanoacetoarylsulfonyl-hydrazides has been investigated. 1-Arylsulfonylamino-pyrazolo[3,4-c]pyridine-2(1H)-ones have also been prepared from the reaction of 4-alkylthio-N-arylsulfonylamino-2-pyridones with hydrazines.

  DOI：

  10.1080/10426500108040593

文献信息

• A NEW GENERAL METHOD FOR SUBSTITUTED 4-ALKYLTHIO-<i>N</i>-ARYLSULPHONYL-AMINO-2-PYRIDONES: REACTION OF KETENE-<i>SS</i>-ACETALS WITH ARYLSULPHONYLHYDRAZIDES
  作者：Galal H. Elgemeie、Hosny A. Ali、Ahmed H. Elghandour、Hassan M. Abdel-aziz

  DOI：10.1080/10426500108040593

  日期：2001.3.1

  A novel and efficient method for the synthesis of substituted 4-alkylthio-N-arylsulphonylamino-2-pyridones via the reaction of ketene-SS-acetals with N-cyanoacetoarylsulfonyl-hydrazides has been investigated. 1-Arylsulfonylamino-pyrazolo[3,4-c]pyridine-2(1H)-ones have also been prepared from the reaction of 4-alkylthio-N-arylsulfonylamino-2-pyridones with hydrazines.