5-氟-2-哌啶-2-基-1H-苯并咪唑 | 885275-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 5-氟-2-哌啶-2-基-1H-苯并咪唑
• 中文别名: 5-氟-2-哌啶-2-基-1H-苯并咪唑二盐酸盐
• 英文名称: 5-Fluoro-2-piperidin-2-YL-1H-benzoimidazole
• 英文别名: 6-fluoro-2-piperidin-2-yl-1H-benzimidazole
• CAS: 885275-05-8
• 化学式: C₁₂H₁₄FN₃
• mdl: MFCD06739001
• 分子量: 219.26
• InChiKey: WHFCKKIVCAMLFF-UHFFFAOYSA-N

物化性质

• 沸点：
  445.0±35.0 °C(Predicted)
• 密度：
  1.241±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  40.7
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT

文献信息

• HCV NS3 PROTEASE INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2780026B1

  公开（公告）日：2019-10-23
• [EN] NEW 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION<br/>[FR] NOUVEAUX PEPTIDES 4-AMINO-4-OXOBUTANOYL UTILES EN TANT QU'INHIBITEURS DE LA RÉPLICATION VIRALE
  申请人：ACHILLION PHARMACEUTICALS INC

  公开号：WO2010068760A2

  公开（公告）日：2010-06-17

  The invention provides 4-amino-4-oxobutanoyl peptides of Formula I and the pharmaceutically salts and hydrates thereof. The variables R, R1, R6-R8, R16, R18, R19, M, n, T, Y, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. The 4-amino-4-oxobutanoyl peptides disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptides and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptides as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptides and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections.