4-[(4-hydroxyphenyl)thio]butanoic acid | 85896-82-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-[(4-hydroxyphenyl)thio]butanoic acid
• 英文别名: 4-(4-hydroxyphenyl)sulfanylbutanoic acid
• CAS: 85896-82-8
• 化学式: C₁₀H₁₂O₃S
• 分子量: 212.269
• InChiKey: FCRZRDFUBJPOFC-UHFFFAOYSA-N

物化性质

• 沸点：
  434.4±30.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[(4-hydroxyphenyl)thio]butanoic acid 、 3-氯-N-甲基苄胺 生成 N-(3-chlorobenzyl)-4-[(4-hydroxyphenyl)thio]-N-methylbutanamide
  参考文献：
  名称：

  NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS

  摘要：

  本发明涉及新型取代芳基衍生物、其制备过程及其用于抑制病毒复制和治疗病毒性疾病或障碍，如HIV和/或HCV感染的用途。

  公开号：

  US20120022054A1

文献信息

• [EN] NOVEL SUBSTITUTED ARYL DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS ANTI-HIV AGENTS<br/>[FR] NOUVEAUX DÉRIVÉS ARYLES SUBSTITUÉS, LEUR PROCÉDÉ DE PRÉPARATION ET LEURS UTILISATIONS THÉRAPEUTIQUES EN TANT QU'AGENTS ANTI-VIH
  申请人：CELLVIR

  公开号：WO2010066847A1

  公开（公告）日：2010-06-17

  The present invention concerns novel substituted aryl derivatives, their process of preparation and their use for inhibiting virus replication and for treating viral diseases or disorders such as HIV and/or HCV infection.

  本发明涉及新型取代芳基衍生物，其制备方法以及用于抑制病毒复制和治疗病毒性疾病或障碍，如HIV和/或HCV感染的用途。
• Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
  申请人：Cellvir

  公开号：EP2196453A1

  公开（公告）日：2010-06-16

  The present invention concerns novel substituted aryl derivatives, their process of preparation and their use for inhibiting integration and for treating viral diseases or disorders such as HIV.

  本发明涉及新型取代芳基衍生物、其制备过程及其用于抑制整合和治疗病毒性疾病或紊乱（如艾滋病毒）的用途。
• Isolation of plasma or serum proteins
  申请人：UPFRONT CHROMATOGRAPHY A/S

  公开号：EP2277912A2

  公开（公告）日：2011-01-26

  The present invention provides a process for the isolation of one or more proteins from a protein solution. The process comprises the steps of: (a) providing a protein solution comprising one or more specific proteins and having a preset pH and a preset ionic strength or conductivity, (b) applying the protein solution to a packed bed or expanded bed column comprising an adsorbent, and (c) obtaining one or more proteins from the column, wherein the protein solution has been supplemented with an alcohol.

  本发明提供了一种从蛋白质溶液中分离一种或多种蛋白质的工艺。该工艺包括以下步骤(a) 提供由一种或多种特定蛋白质组成的蛋白质溶液，该溶液具有预设的 pH 值和预设的离子强度或电导率；(b) 将蛋白质溶液应用于由吸附剂组成的填料床或膨胀床色谱柱；以及 (c) 从色谱柱中获得一种或多种蛋白质，其中蛋白质溶液中添加了酒精。
• ISOLATION OF PLASMA OR SERUM PROTEINS
  申请人：UPFRONT CHROMATOGRAPHY A/S

  公开号：EP1765866A2

  公开（公告）日：2007-03-28
• ISOLATION AND SEPARATION OF MINIMALLY DENATURED POTATO PROTEINS AND PEPTIDES
  申请人：UPFRONT CHROMATOGRAPHY A/S

  公开号：EP2115000A1

  公开（公告）日：2009-11-11