(2Z)-3-amino-3-(4-bromophenyl)prop-2-enenitrile | 71682-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2Z)-3-amino-3-(4-bromophenyl)prop-2-enenitrile
• 英文别名: (Z)-3-amino-3-(4-bromophenyl)prop-2-enenitrile
• CAS: 71682-87-6
• 化学式: C₉H₇BrN₂
• 分子量: 223.072
• InChiKey: AHDJAZMPXGPTEA-UITAMQMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-溴苯腈 以37%的产率得到
  参考文献：
  名称：

  RIDGE D. N.; HANIFIN J. W.; HARTEN L. A.; JOHNSON B. D.; MENSCHIK J.; NIC+, J. MED. CHEM., 1979, 22, NO 11, 1385-1389

  摘要：

  DOI：

文献信息

• [EN] 5, 7-SUBSTITUTED-IMIDAZO [1, 2-C] PYRIMIDINES AS INHIBITORS OF JAK KINASES<br/>[FR] [1,2-C]PYRIMIDINES 5,7-IMIDAZO-SUBSTITUÉES COMME INHIBITEURS DE JAK KINASES
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2011130146A1

  公开（公告）日：2011-10-20

  Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, R7, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

  化合物的化学式I：（应在此处插入化学式），以及其立体异构体和药学上可接受的盐和溶剂化合物，其中R1、R2、R3、R4、R5、R6、R7、X1和X2的含义如规范中所述，是一种或多种JAK激酶的抑制剂，并且在治疗自身免疫疾病、炎症性疾病、移植器官、组织和细胞的排斥反应、以及血液学紊乱和恶性肿瘤及其共病症方面具有用处。
• Silver-promoted regio- and stereoselective aminocyanation of alkynes for the synthesis of β-aminoacrylonitriles using N-isocyanoiminotriphenylphosphorane
  作者：Lingnan Chen、Shanshan Cao、Jingping Zhang、Zikun Wang

  DOI：10.1016/j.tetlet.2019.05.045

  日期：2019.6

  The silver-promoted intermolecular aminocyanation of alkynes for the synthesis of (Z)-β-aminoacrylonitriles is reported, using N-isocyanoiminotriphenylphosphorane (NIITP) as both the nitrile and amine source. The transformation proceeds in moderate to good yields, and in a regio- and stereoselective manner, using a wide range of acetylenes.

  报道了使用N-异氰基氨基三苯基磷烷（NIITP）作为腈源和胺源，通过银促进的炔烃的分子间氨基氰化反应，以合成（Z）-β-氨基丙烯腈。使用多种乙炔，转化以中等至良好的产率进行，并以区域和立体选择性的方式进行。
• 5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES AS INHIBITORS OF JAK KINASES
  申请人：Burgess Laurence E.

  公开号：US20130131039A1

  公开（公告）日：2013-05-23

  Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X 1 and X 2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

  化合物I的公式为（应在此处插入公式），其立体异构体及其药学上可接受的盐和溶剂化物均为JAK激酶的抑制剂，可用于治疗自身免疫性疾病、炎症性疾病、移植器官、组织和细胞的排斥反应，以及血液学疾病和恶性肿瘤及其共病症的治疗。其中，R1、R2、R3、R4、R5、R6、R7、X1和X2的含义如规范中所述。
• Improvements in and relating to (3-aryl-5-isothiazolyl)ureas
  申请人：ELI LILLY AND COMPANY

  公开号：EP0129407A2

  公开（公告）日：1984-12-27

  Novel (3-aryl-5-isothiazolyl)-ureas, which are useful as aquatic algicides, terrestrial herbicides, and aquatic herbicides, are described herein. These ureas are prepared from the corresponding 5-amino-3-arylisothiazoles with a ureido forming reagent. Further provided are methods of use and formulations comprising these urea products.

  本文介绍了可用作水生杀藻剂、陆生除草剂和水生除草剂的新型（3-芳基-5-异噻唑基）脲。这些脲类由相应的 5-氨基-3-芳基异噻唑与脲基形成试剂制备而成。此外，还提供了包含这些脲产品的使用方法和配方。
• 5, 7-SUBSTITUTED-IMIDAZO [1, 2-C]PYRIMIDINES AS INHIBITORS OF JAK KINASES
  申请人：Array Biopharma, Inc.

  公开号：EP2558468A1

  公开（公告）日：2013-02-20