4,4'-[methylenebis(1H-benzimidazole-6,2-diyl)]dianiline | 47733-85-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4,4'-[methylenebis(1H-benzimidazole-6,2-diyl)]dianiline
• 英文别名: MMV665943；MB1_D_665943A-2；4,4'-(1(3)H,1'(3')H-5,5'-methanediyl-bis-benzoimidazol-2-yl)-bis-aniline；4-[6-[[2-(4-aminophenyl)-3H-benzimidazol-5-yl]methyl]-1H-benzimidazol-2-yl]aniline
• CAS: 47733-85-7
• 化学式: C₂₇H₂₂N₆
• 分子量: 430.512
• InChiKey: SCUWNIHBUXBXKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  109
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,4'-[methylenebis(1H-benzimidazole-6,2-diyl)]dianiline 、 1,2-二氰基苯 生成
  参考文献：
  名称：

  FEOFANOV, B. N.;SILING, S. A.;BARASHKOV, N. N.;PONOMAREV, I. I.;NEKRASOVA+, VINITI, 5209-B

  摘要：

  DOI：

文献信息

• Pyrazol-3-ones that activate pro-apoptotic BAX
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US10844053B2

  公开（公告）日：2020-11-24

  This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).

  本申请的特点是吡唑-3-酮化合物能激活促细胞凋亡的 BAX。此外，还介绍了使用此类化合物的方法，例如，用于治疗或预防与细胞凋亡失调（例如，病变或受损细胞凋亡不足或病变或受损细胞基本上没有凋亡）有关的疾病、失调和病症。
• Anti-fungal inhibitors
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US11246857B2

  公开（公告）日：2022-02-15

  Described herein are methods of treating or preventing a fungal infection by administering one or more compounds of the present invention to a subject. The methods of the present invention treat or prevent a fungal infection of C. neoformans, C. gattii, L. prolificans, C. albicans, or a combination thereof, as examples. The compounds of the present invention may be administered to a subject with other agents such as antifungal agents.

  本文描述了通过向受试者施用一种或多种本发明化合物来治疗或预防真菌感染的方法。例如，本发明的方法可治疗或预防新变形真菌、加特氏真菌、增殖真菌、白僵菌或其组合的真菌感染。本发明的化合物可与其他制剂如抗真菌制剂一起施用给受试者。
• EP2766355B1
  申请人：——

  公开号：EP2766355B1

  公开（公告）日：2020-12-23
• Pyrazol-3-ones That Activate Pro-apoptotic BAX
  申请人：Dana Farber Cancer Institute, Inc.

  公开号：US20140357687A1

  公开（公告）日：2014-12-04

  This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).
• PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20190315730A1

  公开（公告）日：2019-10-17

  This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).