5-氟-N-甲基-2-吡啶酮 | 51173-06-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5-氟-N-甲基-2-吡啶酮
• 中文别名: 5-氟-1-甲基-2-吡啶酮
• 英文名称: 5-fluoro-N-methylpyridone
• 英文别名: 1-Methyl-5-fluor-2-pyridon；5-fluoro-1-methyl-1H-pyridin-2-one；5-Fluoro-1-methylpyridin-2(1H)-one；5-fluoro-1-methylpyridin-2-one
• CAS: 51173-06-9
• 化学式: C₆H₆FNO
• mdl: MFCD04972412
• 分子量: 127.118
• InChiKey: MZSVPTRXUHRPHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  室温且干燥环境下使用。

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  1-甲基-2-吡啶酮	1-methyl-2-pyridone	694-85-9	C6H7NO	109.128

反应信息

• 作为产物：
  描述：

  1-甲基-2-吡啶酮 在 fluorine 作用下， 以 溶剂黄146 为溶剂， 反应 7.0h， 以43%的产率得到5-氟-N-甲基-2-吡啶酮
  参考文献：
  名称：

  Kobayashi, Yoshiro; Kumadaki, Itsumaro; Yamashita, Toshinori, Heterocycles, 1982, vol. 17, p. 429 - 430

  摘要：

  DOI：

文献信息

• FACTOR XA INHIBITORS
  申请人：Zhu Bing-Yan

  公开号：US20090298806A1

  公开（公告）日：2009-12-03

  The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

  本发明涉及由公式I表示的化合物及其药学上可接受的盐、溶剂化合物、水合物和前药，这些化合物是凝血因子Xa的抑制剂。本发明还涉及制备这些化合物所使用的中间体，含有这些化合物的药物组合物，预防或治疗一系列由不良血栓形成表征的疾病的方法，以及抑制血样的凝血的方法。
• QUINOXALINE DERIVATIVES AS GPR6 MODULATORS
  申请人：ENVOY THERAPEUTICS, INC.

  公开号：US20150232469A1

  公开（公告）日：2015-08-20

  The present invention provides compounds of Formula (I): that are GPR6 modulators and are therefore useful for the treatment of diseases treatable by modulation of GPR6, in particular treating Parkinson disease, levodopa induced dyskinesias, Huntington's disease, other dyskinesias, akinesias, and motor disorders involving dysfunction of the striatum, schizophrenia and drug addiction. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  本发明提供的化合物为式(I)的GPR6调节剂，因此可用于治疗可通过GPR6调节治疗的疾病，特别是治疗帕金森病、左多巴引起的运动障碍、亨廷顿病、其他运动障碍、无动力障碍以及涉及纹状体功能障碍的运动障碍、精神分裂症和药物成瘾。还提供了含有这种化合物的制药组合物以及制备这种化合物的过程。
• Kinetic Assessment of <i>N</i>-Methyl-2-methoxypyridinium Species as Phosphonate Anion Methylating Agents
  作者：Joseph J. Topczewski、Daniel M. Quinn

  DOI：10.1021/ol400054m

  日期：2013.3.1

  Organophosphate nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Although oxime nucleophiles can reactivate the AChE-phosphyl adduct, the adduct undergoes a reaction called aging. No compounds have been described that reactivate the aged-AChE adduct. A family of 2-methoxypyridinium species which reverse aging in a model system is presented. A kinetic study of this system, which includes an SAR analysis, demonstrates that the reaction is highly tunable based on the ring substituents.
• KOBAYASHI, YOSHIRO;KUMADAKI, ITSUMARO;YAMASHITA, TOSHINORI, HETEROCYCLES, 1982, 17, N ISSUE, 429-430
  作者：KOBAYASHI, YOSHIRO、KUMADAKI, ITSUMARO、YAMASHITA, TOSHINORI

  DOI：——

  日期：——
• US7521470B2
  申请人：——

  公开号：US7521470B2

  公开（公告）日：2009-04-21