2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-methoxy-3-(1,2,4-triazol-1-yl)propan-2-ol | 1159001-23-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-methoxy-3-(1,2,4-triazol-1-yl)propan-2-ol
• CAS: 1159001-23-6
• 化学式: C₁₈H₁₇Cl₂N₃O₃
• 分子量: 394.257
• InChiKey: GDFDTFIZEZPZCB-UHFFFAOYSA-N

物化性质

• 熔点：
  149-150 °C
• 沸点：
  580.8±60.0 °C(predicted)
• 密度：
  1.35±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲醇 、 1-((2-(2-chloro-4-(4-chlorophenoxy)phenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以83.4%的产率得到2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-methoxy-3-(1,2,4-triazol-1-yl)propan-2-ol
  参考文献：
  名称：

  Synthesis and Fungicidal Evaluation of 2-Arylphenyl Ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol Derivatives

  摘要：

  A series of novel 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives were designed and synthesized as candidate fungicides. The new compounds were identified by H-1 NMR spectroscopy and element analysis. Their antifungal activities were evaluated. They exhibited excellent antifungal activities against five common pathogens in comparison with the commercial fungicides tebuconazole and difenoconazole. The antifungal activities of three new triazole alcohol compounds were compared with those of tebuconazole and difenoconazole at a concentration of 1 mu g/mL.

  DOI：

  10.1021/jf900222s

文献信息

• [EN] PROCESS FOR THE PREPARATION OF SUBSTITUTED OXIRANES AND TRIAZOLES<br/>[FR] PROCÉDÉ DE PRÉPARATION D'OXIRANES ET TRIAZOLES SUBSTITUÉS
  申请人：BASF SE

  公开号：WO2014108286A1

  公开（公告）日：2014-07-17

  The present invention relates to a process for the preparation of the compounds (II) from the respective oxo compounds. Furthermore, he invention relates to a process for the preparation of triazole compounds from oxiranes II.

  本发明涉及一种从相应的醛酮化合物制备化合物（II）的方法。此外，该发明涉及一种从环氧烷（II）制备三唑化合物的方法。
• PROCESS FOR THE PREPARATION OF SUBSTITUTED OXIRANES AND TRIAZOLES
  申请人：BASF AGRO B.V.

  公开号：US20160002189A1

  公开（公告）日：2016-01-07

  The present invention relates to a process for the preparation of the compounds II from the respective oxo compounds. Furthermore, he invention relates to a process for the preparation of triazole compounds from oxiranes II.

  本发明涉及一种从相应的氧化物化合物制备化合物II的方法。此外，本发明还涉及一种从环氧丙烷II制备三唑化合物的方法。
• Fungicidal mixtures comprising pyrimidine fungicides
  申请人：BASF SE

  公开号：EP2835052A1

  公开（公告）日：2015-02-11

  The present invention relates to fungicidal mixtures, comprising at least one fungicidally active compound I and at least one pesticide II as defined in the description, and to compositions comprising these mixtures. The invention furthermore relates to the use of the inventive mixtures for controlling phytopathogenic fungi and compositions comprising them. The invention furthermore also relates to compositions comprising the inventive mixtures and seed in an amount of from 1 g to 1000 g active components per 100 kg of seed. The invention furthermore also relates to methods for controlling phytopathogenic fungi, wherein the fungi or the materials, plants, the soil or seed to be protected from fungal attack are treated with an effective amount of a mixture according to the invention. The invention furthermore also relates to processes for preparing the compositions comprising the mixtures according to the invention.

  本发明涉及杀真菌混合物，包括至少一种杀真菌活性化合物 I 和至少一种农药 II（如描述中所定义），以及包含这些混合物的组合物。 本发明还涉及本发明混合物在控制植物病原真菌方面的用途以及包含这些混合物的组合物。本发明还涉及由本发明混合物和种子组成的组合物，其用量为每 100 千克种子 1 克至 1000 克活性成分。此外，本发明还涉及控制植物病原真菌的方法，其中真菌或材料、植物、土壤或种子需用有效量的根据本发明的混合物处理，以防止真菌侵袭。此外，本发明还涉及制备包含根据本发明的混合物的组合物的工艺。
• Agrochemical formulations comprising a 2-ethyl-hexanol alkoxylate
  申请人：BASF SE

  公开号：EP2839745A1

  公开（公告）日：2015-02-25

  The present invention relates to novel compositions, comprising (1) an active ingredient selected from compounds I-1 to I-31; and (2) the 2-ethyl-hexanol alkoxylate of the formula (II). Furthermore, the present invention relates to a process for the preparation of said composition and to the use of the inventive composition in agriculture and to a method of controlling phytopathogenic fungi, wherein the fungi, their habitat or the plants to be protected against fungal attack, the soil or seed are treated with an effective amount of the inventive composition.

  本发明涉及新型组合物，包括(1)选自化合物I-1至I-31的活性成分；和(2)式(II)的2-乙基己醇烷氧基化物。此外，本发明还涉及一种制备所述组合物的工艺和本发明组合物在农业中的用途，以及一种控制植物病原真菌的方法，其中真菌、其栖息地或需要保护以防真菌侵袭的植物、土壤或种子均用有效量的本发明组合物处理。
• USE OF A TRIAZOLE FUNGICIDE ON TRANSGENIC PLANTS
  申请人：BASF SE

  公开号：EP3028573A1

  公开（公告）日：2016-06-08

  The present invention relates to a method for controlling pests and/or increasing the plant health in cultivated plants comprising the application of a triazole fungicide to the plant with at least one modification, parts of such plants, plant propagation materials, or at their locus of growth, wherein the triazole fungicide is selected from the group consisting of I-1, I-2, I-3, I-4, I-5, I-6, I-7, I-8, I-9, I-10, I-11, I-12, I-13, I-14, I-15, I-16, I-17, I-18, I-19, I-20, I-21, I-22, I-23, I-24, I-25, I-26, 1-27, 1-28, 1-29, 1-30 and 1-31.

  本发明涉及一种在栽培植物中控制害虫和/或提高植物健康的方法，该方法包括将三唑类杀菌剂施用到具有至少一种改性的植物、这些植物的部分、植物繁殖材料或其生长部位、其中三唑类杀菌剂选自由I-1、I-2、I-3、I-4、I-5、I-6、I-7、I-8、I-9、I-10、I-11、I-12、I-13、I-14、I-15、I-16、I-17、I-18、I-19、I-20、I-21、I-22、I-23、I-24、I-25、I-26、1-27、1-28、1-29、1-30和1-31组成的组。