N-[(2-methoxyphenyl)methyl]pyrazine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[(2-methoxyphenyl)methyl]pyrazine-2-carboxamide
• 化学式: C₁₃H₁₃N₃O₂
• mdl: MFCD06005083
• 分子量: 243.26
• InChiKey: AEBUQSFRBBMHIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PYRAZINE COMPOUNDS AND USES THEREOF
  申请人：DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD

  公开号：EP3837250A1

  公开（公告）日：2021-06-23
• [EN] PYRAZINE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS DE PYRAZINE ET LEURS UTILISATIONS
  申请人：DIZAL JIANGSU PHARMACEUTICAL CO LTD

  公开号：WO2020035052A1

  公开（公告）日：2020-02-20

  The present disclosure novel pyrazine compounds targeting adenosine receptors (especially A1 and A2, particularly A2a). The present disclosure also relates to pharmaceutical compositions comprising one or more of the compounds as an active ingredient, and use of the compounds in the treatment of adenosine receptor (AR) associated diseases, for example cancer such as NSCLC, RCC, prostate cancer, and breast cancer.