Slightly corrosive to copper, lead, mild steel, tin and zinc, but will not attack fiberglass, reinforced polyester, rigid PVC, or the usual lacquers used for lining drums. Incompatible with most mineral carriers, except synthetic silicas such as 'Colloidal Silica K320' and 'Hisil 233'.
STUDIES WITH (32)P-LABELED CIODRIN...LACTATING EWES AND LACTATING GOATS SHOWED HYDROLYTIC FISSION TO AFFORD CORRESPONDING MONOMETHYLPHOSPHATE AND DIMETHYLPHOSPHATE.
IN LACTATING EWE AFTER ORAL ADMIN, (32)P-CIODRIN IS RAPIDLY METABOLIZED... PRINCIPAL METABOLITE WAS DIMETHYL PHOSPHORIC ACID CONSISTING OF 60-90% OF TOTAL RADIOACTIVITY IN URINE. ANOTHER IMPORTANT METABOLITE WAS 3-(DIMETHOXYPHOSPHINYLOXY)CROTONIC ACID WHICH APPEARED AS 11% OF METABOLITES AFTER 3 HR, DECR TO 3% AFTER 6 HR.
Symptomatology: 1. Nausea...vomiting, abdominal cramps, diarrhea, excessive salivation... 2. Headache, giddiness, vertigo & weakness. 3. Rhinorrhea & sensation of tightness in chest are common in inhalation exposure. 4. Blurring or dimness of vision, miosis... Tearing, ciliary muscle spasm, loss of accommodation & ocular pain... Mydriasis...sometimes seen...probably due to sympatho-adrenal discharge. 5. Bradycardia or tachycardia. Varying degrees of AV heart block are described, as well as atrial arrhythmias. 6. Loss of muscle coordination, slurring of speech, fasciculations & twitching of muscles (particularly of tongue & eyelids, & generalized profound weakness. 7. Mental confusion, disorientation & drowsiness. /Parathion/
Symptomatology: 8. Difficulty in breathing, excessive secretion of saliva & of resp tract mucus, oronasal frothing, cyanosis, pulmonary rales & rhonchi & hypertension (presumably due to asphyxia). 9. Random jerky movements, incontinence, convulsions, & coma. 10. Death primarily due to resp arrest arising from failure of resp center, paralysis of resp muscles, intense bronchoconstriction or all three. /Parathion/
STUDIES WITH (32)P-LABELED CIODRIN...IN LACTATING EWES AND...GOATS SHOWED HYDROLYTIC FISSION TO...THE CORRESPONDING MONOMETHYLPHOSPHATE AND DIMETHYLPHOSPHATE. IN BOTH SPECIES, MAJOR ELIMINATIVE ROUTE WAS URINARY, AND VERY SMALL AMT OF UNCHANGED /CIODRIN/ IN MILK CONSISTED ONLY OF BETA-ISOMER.
STUDY OF ABSORPTION, ELIMINATION & METABOLISM OF ORALLY ADMIN (32)P LABELED CIODRIN IN LACTATING EWE INDICATED MODERATE ABSORPTION & RAPID ELIMINATION. DIMETHYL PHOSPHORIC ACID ACCOUNTED FOR 61-90% OF RADIOACTIVITY IN URINE. ... SIMILAR RESULTS WERE OBTAINED...WITH A LACTATING GOAT.
Compounds of formula I
wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as insecticides and can be prepared in a manner known per se.
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
申请人：Dow AgroSciences LLC
公开号：US20180279612A1
公开（公告）日：2018-10-04
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
