6-(4-formylphenyl)uridine | 1443036-59-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 6-(4-formylphenyl)uridine
• 英文别名: 4-[3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,6-dioxopyrimidin-4-yl]benzaldehyde
• CAS: 1443036-59-6
• 化学式: C₁₆H₁₆N₂O₇
• 分子量: 348.312
• InChiKey: VCQBNTRSCDKVBZ-NMFUWQPSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-甲酰基苯硼酸 、 6-iodouridine 在 sodium tetrachloropalladate(II) 、 potassium hydroxide 作用下， 以 水 为溶剂， 反应 1.5h， 以80%的产率得到6-(4-formylphenyl)uridine
  参考文献：
  名称：

  Synthesis of 6-aryluridines via Suzuki–Miyaura cross-coupling reaction at room temperature under aerobic ligand-free conditions in neat water

  摘要：

  A new and efficient ligandless cross-coupling reaction of 6-iodouridine with various boronic acids in the presence of Na2PdCl4 was performed at room temperature in aerobic water. The target 6-aryl analogues were obtained in moderate to good yields depending on the boronic acid nature. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.066

文献信息

• Synthesis of 6-aryluridines via Suzuki–Miyaura cross-coupling reaction at room temperature under aerobic ligand-free conditions in neat water
  作者：Gérald Enderlin、Guillaume Sartori、Gwénaëlle Hervé、Christophe Len

  DOI：10.1016/j.tetlet.2013.04.066

  日期：2013.6

  A new and efficient ligandless cross-coupling reaction of 6-iodouridine with various boronic acids in the presence of Na2PdCl4 was performed at room temperature in aerobic water. The target 6-aryl analogues were obtained in moderate to good yields depending on the boronic acid nature. (c) 2013 Elsevier Ltd. All rights reserved.