3-{2-[3-(trifluoromethyl)benzyl]imidazo[2,1-b][1,3]thiazol-6-yl}-2H-chromen-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-{2-[3-(trifluoromethyl)benzyl]imidazo[2,1-b][1,3]thiazol-6-yl}-2H-chromen-2-one
• 英文别名: 3-[2-[[3-(trifluoromethyl)phenyl]methyl]imidazo[2,1-b][1,3]thiazol-6-yl]chromen-2-one
• 化学式: C₂₂H₁₃F₃N₂O₂S
• mdl: MFCD04186576
• 分子量: 426.4
• InChiKey: PIJARZUKYSZRHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  71.8
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Methods and compositions to treat cancer
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：US10391084B2

  公开（公告）日：2019-08-27

  Embodiments provided herein relate to methods and compositions for treating cancer. Some embodiments include treating lung cancers and renal cancers.

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• Methods and compositions for treating mesothelioma and small lung cancer that express midkine
  申请人：Children's Hospital Medical Center

  公开号：US10668078B2

  公开（公告）日：2020-06-02

  Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.

  本文提供的实施方案涉及治疗间皮瘤和/或表达midkine的小细胞肺癌的方法和组合物。
• METHODS AND COMPOSITIONS TO TREAT CANCER
  申请人：CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：US20160113909A1

  公开（公告）日：2016-04-28

  Embodiments provided herein relate to methods and compositions for treating cancer. Some embodiments include treating lung cancers and renal cancers.
• [EN] METHODS AND COMPOSITIONS TO TREAT CANCER<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DU CANCER
  申请人：CHILDRENS HOSP MEDICAL CENTER

  公开号：WO2014205132A2

  公开（公告）日：2014-12-24

  Embodiments provided herein relate to methods and compositions for treating cancer. Some embodiments include treating lung cancers and renal cancers.