2-bromo-N-(2-bromophenyl)-5-fluorobenzamide | 1040342-73-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-bromo-N-(2-bromophenyl)-5-fluorobenzamide
• CAS: 1040342-73-1
• 化学式: C₁₃H₈Br₂FNO
• mdl: MFCD11120414
• 分子量: 373.019
• InChiKey: RDXDOQKOZTVXNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-bromo-N-(2-bromophenyl)-5-fluorobenzamide 、 甲胺 在 potassium phosphate 、 1,10-菲罗啉 、 copper(l) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以53%的产率得到2-fluoro-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one
  参考文献：
  名称：

  The N-Aryl Aminocarbonyl ortho-Substituent Effect in Cu-Catalyzed Aryl Amination and Its Application in the Synthesis of 5-Substituted 11-Oxo-dibenzodiazepines

  摘要：

  Double amination of ortho-substituted aryl bromides proceeded under mild conditions to afford 5-substituted 11-oxo-dibenzodiazepines, which revealed that there is a strong ortho-substituent effect caused by N-aryl aminocarbonyl groups during copper-catalyzed aryl amination.

  DOI：

  10.1021/ol202721h

文献信息

• The <i>N</i>-Aryl Aminocarbonyl <i>ortho</i>-Substituent Effect in Cu-Catalyzed Aryl Amination and Its Application in the Synthesis of 5-Substituted 11-Oxo-dibenzodiazepines
  作者：Xiaoqiong Diao、Lanting Xu、Wei Zhu、Yongwen Jiang、Haoyang Wang、Yinlong Guo、Dawei Ma

  DOI：10.1021/ol202721h

  日期：2011.12.16

  Double amination of ortho-substituted aryl bromides proceeded under mild conditions to afford 5-substituted 11-oxo-dibenzodiazepines, which revealed that there is a strong ortho-substituent effect caused by N-aryl aminocarbonyl groups during copper-catalyzed aryl amination.