3-({4-[(4,6-dioxo-2-thioxotetrahydropyrimidin-5(2H)-ylidene)methyl]-2-methoxyphenoxy}methyl)benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-({4-[(4,6-dioxo-2-thioxotetrahydropyrimidin-5(2H)-ylidene)methyl]-2-methoxyphenoxy}methyl)benzoic acid
• 英文别名: 3-[[4-[(4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)methyl]-2-methoxyphenoxy]methyl]benzoic acid
• 化学式: C₂₀H₁₆N₂O₆S
• 分子量: 412.4
• InChiKey: STRDOMDYZZZBCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  146
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• NOVEL COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INSULIN RESISTANCE
  申请人：UNIVERSITE PARIS DESCARTES

  公开号：US20200030297A1

  公开（公告）日：2020-01-30

  The invention relates to a compound inhibiting the interaction between a Grb14 protein and an insulin receptor of Formula (I) or Formula (II), their salts, solvates, and/or diastereoisomers, for use for therapeutic purposes, in particular for the treatment of insulin resistance, and to pharmaceutical compositions containing such compounds.

  该发明涉及一种抑制Grb14蛋白与化学式（I）或化学式（II）的胰岛素受体之间相互作用的化合物，其盐、溶剂合物和/或对映异构体，用于治疗目的，特别是用于治疗胰岛素抵抗，并且涉及含有这种化合物的药物组合物。
• Compounds, compositions and methods for treating insulin resistance
  申请人：UNIVERSITE PARIS DESCARTES

  公开号：US11020378B2

  公开（公告）日：2021-06-01

  The invention relates to a compound inhibiting the interaction between a Grb14 protein and an insulin receptor of Formula (I) or Formula (II), their salts, solvates, and/or diastereoisomers, for use for therapeutic purposes, in particular for the treatment of insulin resistance, and to pharmaceutical compositions containing such compounds.

  本发明涉及一种抑制 Grb14 蛋白与式（I）或式（II）胰岛素受体之间相互作用的化合物、 它们的盐、溶解物和/或非对映异构体，用于治疗目的，特别是治疗胰岛素抵抗，以及含有此类化合物的药物组合物。
• Compositions and methods for inhibiting PTPN22
  申请人：YALE UNIVERSITY

  公开号：US11311543B2

  公开（公告）日：2022-04-26

  The present invention provides compositions and methods for inhibiting PTPN22 for restoring human central B-cell tolerance or for treating or preventing an autoimmune disease or disorder.

  本发明提供了抑制 PTPN22 的组合物和方法，用于恢复人类中枢 B 细胞耐受性或治疗或预防自身免疫性疾病或紊乱。
• COMPOSITIONS AND METHODS FOR INHIBITING PTPN22
  申请人：YALE UNIVERSITY

  公开号：US20200316070A1

  公开（公告）日：2020-10-08

  The present invention provides compositions and methods for inhibiting PTPN22 for restoring human central B-cell tolerance or for treating or preventing an autoimmune disease or disorder.