Methylphenyl-N-methyl-N-phenylphosphoramidat | 39220-36-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methylphenyl-N-methyl-N-phenylphosphoramidat
• 英文别名: N-[methoxy(phenoxy)phosphoryl]-N-methylaniline
• CAS: 39220-36-5
• 化学式: C₁₄H₁₆NO₃P
• 分子量: 277.26
• InChiKey: YOSKRNBLFUADRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 Methylphenyl-N-methyl-N-phenylphosphoramidat
  参考文献：
  名称：

  A general method for the synthesis of O-alkyl N,O′-arylphosphoramidates and its application to the synthesis of a transition state analogue for carbamate hydrolysis

  摘要：

  O-alkyl N,O'-arylphosphoramidates were synthesized by reacting phenol and aniline derivatives with alkyldichlorophosphites to form phosphoramidites followed by oxidation with m-CPBA. Selective cleavage of the alkyl group under mild, neutral conditions afforded the corresponding N,O-arylphosphoramidic acids. This methodology was used to synthesize a N,O-arylphosphoramidate transition state analogue for carbamate hydrolysis. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00123-9

文献信息

• A general method for the synthesis of O-alkyl N,O′-arylphosphoramidates and its application to the synthesis of a transition state analogue for carbamate hydrolysis
  作者：Scott D. Taylor、Mei-Jin Chen、A. Nicole Dinaut、Robert A. Batey

  DOI：10.1016/s0040-4020(98)00123-9

  日期：1998.4

  O-alkyl N,O'-arylphosphoramidates were synthesized by reacting phenol and aniline derivatives with alkyldichlorophosphites to form phosphoramidites followed by oxidation with m-CPBA. Selective cleavage of the alkyl group under mild, neutral conditions afforded the corresponding N,O-arylphosphoramidic acids. This methodology was used to synthesize a N,O-arylphosphoramidate transition state analogue for carbamate hydrolysis. (C) 1998 Elsevier Science Ltd. All rights reserved.