10-(1H-benzo[d]imidazol-2-yl)-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11-one | 85642-10-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 10-(1H-benzo[d]imidazol-2-yl)-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11-one
• 英文别名: 5-(1H-benzimidazol-2-yl)-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraen-4-one
• CAS: 85642-10-0
• 化学式: C₂₂H₁₉N₃O₂
• 分子量: 357.412
• InChiKey: GPGSAESYFKTPBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  58.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氰甲基苯并咪唑 在 哌啶 、 盐酸 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 10-(1H-benzo[d]imidazol-2-yl)-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11-one
  参考文献：
  名称：

  Synthesis and anti-angiogenesis activity of coumarin derivatives

  摘要：

  A series of 7-diethylaminocoumarin compounds were synthesized and the cytotoxicities were tested against human umbilical vein endothelial cell (HUVEC) and some cancer cells. We found that the introduction of cyano groups at the 4-position will promote the bioactivity. In particular, compounds 9 and 10 strongly inhibited the proliferation of various cancer cell lines, and 12 and 15 showed a high selectivity for HUVEC. Therefore, these coumarin molecules can be utilized as lead compounds to develop potential nontoxic angiogenesis inhibitors and small molecular ligands to target HUVEC. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.06.007

文献信息

• Aminocoumarin compound, and aminocoumarin compound-containing resin particles
  申请人：Konica Minolta, Inc.

  公开号：US11434376B2

  公开（公告）日：2022-09-06

  The present invention provides: an aminocoumarin compound having a structure represented by the following formula (1); and an aminocoumarin compound-containing resin particle containing the aminocoumarin compound and a resin particle containing the aminocoumarin compound. In formula (1), Rs each independently represent a hydrogen atom or a methyl group, Q represents a sulfur atom, an oxygen atom, or N—R1, and R1 represents a hydrogen atom or a methyl group. The aminocoumarin compound of the present invention is a fluorescent dye that has a longer excitation wavelength than a conventionally known sulfonated coumarin-based compound and is effectively excited at a wavelength of 475 nm or more, particularly at a wavelength around 500 nm. The aminocoumarin compound of the present invention is a fluorescent dye that is excited, for example, at a wavelength of 475 to 510 nm and can be observed in a green light emission region of 510 to 540 nm using the wavelength characteristic, and can be expected to be suitably utilized in immunostaining or the like.

  本发明提供：具有下式（1）所代表结构的氨基香豆素化合物；以及含有该氨基香豆素化合物的含氨基香豆素化合物树脂颗粒和含有该氨基香豆素化合物的树脂颗粒。式（1）中，Rs 各自独立地代表氢原子或甲基，Q 代表硫原子、氧原子或 N-R1，R1 代表氢原子或甲基。本发明的氨基香豆素化合物是一种荧光染料，其激发波长比传统已知的磺化香豆素基化合物更长，可在 475 纳米或更高波长处有效激发，特别是在 500 纳米左右的波长处。本发明的氨基香豆素化合物是一种在例如 475 至 510 纳米的波长下激发的荧光染料，利用波长特性可观察到 510 至 540 纳米的绿光发射区域，可望适当用于免疫染色或类似用途。
• NEW ORGANIC COMPOUNDS FOR ELECTROLUMINESCENCE AND ORGANIC ELECTROLUMINESCENT DEVICES USING THE SAME
  申请人：LG Chem, Ltd.

  公开号：EP1501821B1

  公开（公告）日：2016-07-20
• Organic compounds for electroluminescence and organic electroluminescent devices using the same
  申请人：Kim Ji-Eun

  公开号：US20070037012A1

  公开（公告）日：2007-02-15

  Disclosed is a novel group of compounds having a general structure of anthracene body substituted with at least one thiophenyl group, which can be further substituted with various substituent groups. These new compounds are generally compatible with organic electroluminescence. Also disclosed are organic electroluminescent devices and method of making the same. The organic electroluminescent devices include at least one of the compounds in various layers thereof. Organic electroluminescent devices employing the new compounds in their light-emitting layers show outstanding stability.
• ELECTROLUMINESCENT ELEMENT
  申请人：Seo Satoshi

  公开号：US20100194266A1

  公开（公告）日：2010-08-05

  An electroluminescent element which comprises host materials and guest materials in a part of an electroluminescent layer, and which is superior in device characteristics such as luminous efficiency and luminous characteristics to those of the conventional electroluminescent element is provided. According to the present invention, device characteristics (luminous efficiency, luminous characteristics, or the like) of an electroluminescent element is improved by using host materials and guest materials which have a common skeleton (represented by the following general formula 1) for an electroluminescent layer interposed between a pair of electrodes in the electroluminescent element. wherein R1 is a hydrogen atom, or the like, R2 to R5, each of which may be the same or different, are individually a hydrogen atom, or the like, and Ar1 is an aryl group which may have a substituent, or the like.
• Electroluminescent Device
  申请人：Seo Satoshi

  公开号：US20110284833A1

  公开（公告）日：2011-11-24

  An electroluminescent element which comprises host materials and guest materials in a part of an electroluminescent layer, and which is superior in device characteristics such as luminous efficiency and luminous characteristics to those of the conventional electroluminescent element is provided. According to the present invention, device characteristics (luminous efficiency, luminous characteristics, or the like) of an electroluminescent element is improved by using host materials and guest materials which have a common skeleton (represented by the following general formula 1) for an electroluminescent layer interposed between a pair of electrodes in the electroluminescent element. wherein R1 is a hydrogen atom, or the like, R2 to R5, each of which may be the same or different, are individually a hydrogen atom, or the like, and Ar1 is an aryl group which may have a substituent, or the like.