N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)acetamide | 578700-80-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)acetamide
• 英文别名: N-(2-benzoyl-4-nitrophenyl)-2-(4-methylpiperazin-1-yl)acetamide
• CAS: 578700-80-8
• 化学式: C₂₀H₂₂N₄O₄
• 分子量: 382.419
• InChiKey: KXNCGGOLFIEZLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  98.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)acetamide 在 tin(II) chloride dihydrate 、 碳酸氢钠 作用下， 以 乙酸乙酯 、 水 为溶剂， 以34%的产率得到N-(4-amino-2-benzoylphenyl)-2-(4-methyl-1-piperazinyl)acetamide
  参考文献：
  名称：

  Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone

  摘要：

  Here, we describe a series of readily obtainable benzophenone derivatives with antimalarial and antitrypanosomal activity. The most active compounds display submicromolar activity against Plasmodium falciparum. Micromolar activity is obtained against Trypanosoma brucei. Main problem of the compounds is low selectivity. However, there are indications that separation of antimalarial and cytotoxic activity might by possible. In addition, some compounds inhibit human ABC transporter with nanomolar activity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.09.043
• 作为产物：
  描述：

  N-甲基哌嗪 、 N-(2-苯甲酰基-4-硝基苯基)-2-氯乙酰胺 以 乙腈 为溶剂， 以58%的产率得到N-(2-benzoyl-4-nitrophenyl)-2-(4-methyl-1-piperazinyl)acetamide
  参考文献：
  名称：

  Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone

  摘要：

  Here, we describe a series of readily obtainable benzophenone derivatives with antimalarial and antitrypanosomal activity. The most active compounds display submicromolar activity against Plasmodium falciparum. Micromolar activity is obtained against Trypanosoma brucei. Main problem of the compounds is low selectivity. However, there are indications that separation of antimalarial and cytotoxic activity might by possible. In addition, some compounds inhibit human ABC transporter with nanomolar activity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.09.043

文献信息

• Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone
  作者：Mirko Altenkämper、Benjamin Bechem、Johann Perruchon、Swetlana Heinrich、Andrea Mädel、Regina Ortmann、Hans-Martin Dahse、Ellen Freunscht、Yulin Wang、Jennifer Rath、August Stich、Manuela Hitzler、Peter Chiba、Michael Lanzer、Martin Schlitzer

  DOI：10.1016/j.bmc.2009.09.043

  日期：2009.11

  Here, we describe a series of readily obtainable benzophenone derivatives with antimalarial and antitrypanosomal activity. The most active compounds display submicromolar activity against Plasmodium falciparum. Micromolar activity is obtained against Trypanosoma brucei. Main problem of the compounds is low selectivity. However, there are indications that separation of antimalarial and cytotoxic activity might by possible. In addition, some compounds inhibit human ABC transporter with nanomolar activity. (C) 2009 Elsevier Ltd. All rights reserved.