(E)-2-(o-Tolyl)ethene-1-sulfonic acid | 139555-08-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-2-(o-Tolyl)ethene-1-sulfonic acid
• 英文别名: (E)-2-(2-methylphenyl)ethenesulfonic acid
• CAS: 139555-08-1
• 化学式: C₉H₁₀O₃S
• 分子量: 198.243
• InChiKey: RPMREWAGXHVNIE-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基苯乙烯 在 三氧化硫 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成 (E)-2-(o-Tolyl)ethene-1-sulfonic acid
  参考文献：
  名称：

  苯乙烯及其衍生物与三氧化硫的反应；初始产品的表征和化学性质†

  摘要：

  以二氯甲烷为溶剂，当量为1.5 mol，研究了苯乙烯衍生物1a-14a与三氧化硫的反应，反应温度范围为-60至25°C。二恶烷作为反应性调节剂。苯乙烯（1a）在低温下的反应产生了羰基硫酸盐1c，它是最终形成（E）-2-苯基乙烯-1-磺酸（1d）的唯一可观察到的中间体。（苯基）取代的苯乙烯3a-5a清楚地证明了β-磺内酯3b-5b作为唯一的起始产物的存在，导致了相应的羰基硫酸盐3c-5c。最初形成的β-磺内酯b在苯乙烯衍生物3a-5a，9a和10a与1.0摩尔当量的反应中进行反应。SO 3歧化，得到等量的相应的羰基硫酸盐和起始苯乙烯。认为这表明在β-磺内酯和起始苯乙烯之间存在平衡。1-甲基取代的苯乙烯基团11a-13a的基团是通常观察到的将初始中间体最终转化为2-磺酸d的例外，因为它们给出了相应的3-磺酸f。

  DOI：

  10.1002/recl.19921110106

文献信息

• LATEX PARTICLE FOR MEASUREMENT REAGENT, SENSITIZED LATEX PARTICLE, AND MEASUREMENT REAGENT FOR IMMUNONEPHELOMETRY
  申请人：Sekisui Medical Co., Ltd.

  公开号：EP2693214A1

  公开（公告）日：2014-02-05

  An object of the present invention is to provide a latex particle for a measurement reagent with which highly sensitive measurement can be performed even in measuring a measurement sample containing a test substance in a dilute concentration. The preset invention relates to a latex particle for a measurement reagent including a copolymer obtained by copolymerizing a monomer mixture containing the following polymerizable monomers (a) to (c): (a) a polymerizable monomer having a phenyl group; (b) a polymerizable monomer having a phenyl group and a sulfonate; and (c) a polymerizable monomer having a naphthyl group, in an aqueous medium containing 7.5 to 25% by weight of C1-4 alcohol without using a surfactant.

  本发明的目的是提供一种用于测量试剂的胶乳颗粒，即使在测量含有稀释浓度测试物质的测量样品时，也能用它进行高灵敏度测量。 本发明涉及一种用于测量试剂的胶乳颗粒，它包括一种共聚物，该共聚物是通过共聚含有以下可聚合单体(a)至(c)的单体混合物而得到的： (a) 具有苯基的可聚合单体； (b) 具有苯基和磺酸盐的可聚合单体；和 (c) 具有萘基的可聚合单体、 在不使用表面活性剂的情况下，在含有 7.5%至 25%（按重量计）C1-4 醇的水介质中。
• LATEX PARTICLES FOR MEASURING PARTICLE AGGLOMERATION
  申请人：Sekisui Medical Co., Ltd.

  公开号：EP2799874A1

  公开（公告）日：2014-11-05

  Latex particles for a particle agglutination assay, with which it is possible to carry out high-sensitivity assay while highly suppressing a non-specific reaction are disclosed. The latex particles being obtained by emulsion polymerization with a polymerizable monomer having a phenyl group, and a polymerizable monomer having a phenyl group and a sulfonate in an aqueous medium including a nonionic surfactant at a concentration of 0.005 to 0.02 wt% based on the aqueous medium, the latex particles having an average particle size of 0.005 to 1.0 µm.

  本发明公开了用于颗粒凝集试验的胶乳颗粒，使用这种颗粒可以进行高灵敏度试验，同时高度抑制非特异性反应。这种胶乳颗粒是通过在包括非离子表面活性剂的水介质中与具有苯基的可聚合单体、具有苯基的可聚合单体和磺酸盐进行乳液聚合而得到的，水介质中的非离子表面活性剂的浓度为 0.005 至 0.02 wt%，胶乳颗粒的平均粒径为 0.005 至 1.0 µm。
• LATEX PARTICLES FOR AGGLUTINATION ASSAY
  申请人：Sekisui Medical Co., Ltd.

  公开号：EP2833146A1

  公开（公告）日：2015-02-04

  A latex particle for high-sensitive agglutination assay and a reagent for agglutination assay including the particle are provided. The latex particle barely initiates non-specific reactions and can readily prepare diagnostic agents. A latex particle for agglutination assay including a polymerizable monomer having a phenyl group, a polymerizable monomer having a phenyl group and a salt of sulfonic acid, and a polymerizable monomer represented by Formula (1):         CH2=CR1-COO (CH2CH2O)n-R2     (1) where R1 represents a hydrogen atom or a methyl group; R2 represents a hydrogen atom or a methyl group; and n is 1≤n<20, wherein the density of functional groups derived from the polymerizable monomer represented by Formula (1) on the surface of the particle is 0.05 to 0.5 µmol/m2.

  本研究提供了一种用于高灵敏度凝集试验的乳胶颗粒和一种包括该颗粒的凝集试验试剂。这种胶乳颗粒几乎不会引发非特异性反应，而且可以方便地制备诊断试剂。凝集试验用胶乳颗粒包括具有苯基的可聚合单体、具有苯基和磺酸盐的可聚合单体以及由式（1）表示的可聚合单体： CH2=CR1-COO (CH2CH2O)n-R2 (1) 其中 R1 代表氢原子或甲基；R2 代表氢原子或甲基；n 为 1≤n＜20，其中粒子表面由式（1）代表的可聚合单体衍生的官能团的密度为 0.05 至 0.5 µmol/m2。
• LATEX PARTICLES FOR PARTICLE AGGREGATION MEASUREMENT
  申请人：Sekisui Medical Co., Ltd.

  公开号：EP2902785A1

  公开（公告）日：2015-08-05

  A particulate latex for high-sensitive agglutination assay that barely poses non-specific reactions and can readily prepare diagnostic reagents, and a reagent for agglutination assay including the particle are provided. A particulate latex for agglutination assay, including a first polymerizable monomer having a phenyl group, a second polymerizable monomer having a phenyl group and a salt of sulfonic acid, and a third polymerizable monomer represented by Formula (1):         CH2=CR1-COOCH2CH2O(PO2)OCH2CH2-N(CH3)     (1) where R1 represents a hydrogen atom or a methyl group, wherein the density of functional groups in the third polymerizable monomer represented by Formula (1) on the surface of the particulate latex is 0.003 to 0.05 µmol/m2.

  本发明提供了一种几乎不会引起非特异性反应并能方便地制备诊断试剂的用于高灵敏度凝集试验的微粒胶乳，以及一种包括该微粒的凝集试验试剂。凝集试验用微粒胶乳，包括具有苯基的第一可聚合单体、具有苯基和磺酸盐的第二可聚合单体以及由式（1）表示的第三可聚合单体： CH2=CR1-COOCH2CH2O(PO2)OCH2CH2-N(CH3) (1) 其中 R1 代表氢原子或甲基、 式（1）代表的第三种可聚合单体在微粒胶乳表面上的官能团密度为 0.003 至 0.05 微摩尔/平方米。
• METHOD OF STORING LATEX PARTICLE DISPERSION LIQUID
  申请人：JSR Corporation

  公开号：EP3564676A1

  公开（公告）日：2019-11-06

  To provide a novel technique with which the generation of aggregates over time in a dispersion liquid can be suppressed and a target substance can be detected with high sensitivity even if latex particles that have been stored are used. A method for storing in a container a latex particle dispersion liquid in which latex particles for an extracorporeal diagnostic agent are dispersed, the latex particles having a volume average particle size of 10 to 1000 nm and including a polymer containing 70 to 100% by mass of monomer units each derived from a monomer having an aryl group relative to the total monomer units, which is characterized in that the particle dispersion liquid is stored in the container by setting a ratio of a volume of a void space obtained by excluding a volume occupied by the particle dispersion liquid from an internal volume of the container to 0 to 25% (v/v) relative to the internal volume of the container.

  提供一种新技术，利用该技术，即使使用已储存的乳胶颗粒，也能抑制分散液中随时间推移产生的聚集物，并能以高灵敏度检测目标物质。一种在容器中储存乳胶颗粒分散液的方法，在分散液中分散有用于体外诊断试剂的乳胶颗粒，乳胶颗粒的体积平均粒径为 10 至 1000 nm，包括一种聚合物，该聚合物含有 70 至 100% 质量的单体单元，每个单体单元都来自具有芳基的单体、其特征在于，在容器中储存颗粒分散液时，将容器内部容积中不包括颗粒分散液所占容积的空隙容积与容器内部容积的比率设定为 0 至 25% (v/v)。