5,5,6,6,7,7-hexafluoro-6,7-dihydro-5H-cyclopenta[b]pyridine | 1492128-10-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5,5,6,6,7,7-hexafluoro-6,7-dihydro-5H-cyclopenta[b]pyridine
• 英文别名: 5,5,6,6,7,7-Hexafluorocyclopenta[b]pyridine；5,5,6,6,7,7-hexafluorocyclopenta[b]pyridine
• CAS: 1492128-10-5
• 化学式: C₈H₃F₆N
• 分子量: 227.109
• InChiKey: XCWNMHLXMRJRQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  [(acetonitrile)₂Zn((CF₂)₃)₂Zn(acetonitrile)₂] 、 2,3-二碘吡啶 在 1,10-菲罗啉 、 copper(l) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以93%的产率得到5,5,6,6,7,7-hexafluoro-6,7-dihydro-5H-cyclopenta[b]pyridine
  参考文献：
  名称：

  Mild, Safe, and Versatile Reagents for (CF₂)_n Transfer and the Construction of Fluoroalkyl-Containing Rings

  摘要：

  The preparation of new dizinc reagents [(MeCN)(2)Zn((CF2)(n))(2)Zn(MeCN)(2)] (n = 3, 4, and 6) is reported. We show that the C4 reagent can readily transmetalate nickel to form a mononuclear perfluoronickela-cycle. We also demonstrate that the reagents can be used to prepare novel fluoroorganics containing either perfluoroalkyl ring systems or perfluoroalkyl linked arenes under relatively mild conditions.

  DOI：

  10.1021/om401016k

文献信息

• Mild, Safe, and Versatile Reagents for (CF₂)_<i>n</i> Transfer and the Construction of Fluoroalkyl-Containing Rings
  作者：Peter T. Kaplan、Long Xu、Bo Chen、Katherine R. McGarry、Siqi Yu、Huan Wang、David A. Vicic

  DOI：10.1021/om401016k

  日期：2013.12.23

  The preparation of new dizinc reagents [(MeCN)(2)Zn((CF2)(n))(2)Zn(MeCN)(2)] (n = 3, 4, and 6) is reported. We show that the C4 reagent can readily transmetalate nickel to form a mononuclear perfluoronickela-cycle. We also demonstrate that the reagents can be used to prepare novel fluoroorganics containing either perfluoroalkyl ring systems or perfluoroalkyl linked arenes under relatively mild conditions.