3-bromo-1-(2-chlorophenyl)-N-[4-cyano-2-methyl-6-[(methylamino)-carbonyl]phenyl]-1H-pyrazol-5-carboxamide | 871238-03-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-bromo-1-(2-chlorophenyl)-N-[4-cyano-2-methyl-6-[(methylamino)-carbonyl]phenyl]-1H-pyrazol-5-carboxamide
• 英文别名: 3-bromo-1-(2-chlorophenyl)-N-[4-cyano-2-methyl-6-[(methylamino)-carbonyl]phenyl]-1H-pyrazole-5-carboxamide；5-bromo-2-(2-chlorophenyl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]pyrazole-3-carboxamide
• CAS: 871238-03-8
• 化学式: C₂₀H₁₅BrClN₅O₂
• 分子量: 472.728
• InChiKey: KQMRZBODTSUMOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  99.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-bromo-1-(2-chlorophenyl)-N-[4-cyano-2-methyl-6-[((1-methylethyl)amino)carbonyl]phenyl]-1H-pyrazol-5-carboxamide 、 甲胺 以 四氢呋喃 、 乙腈 为溶剂， 反应 0.5h， 生成 3-bromo-1-(2-chlorophenyl)-N-[4-cyano-2-methyl-6-[(methylamino)-carbonyl]phenyl]-1H-pyrazol-5-carboxamide
  参考文献：
  名称：

  [EN] ANTHRANILAMIDE INSECTICIDES
  [FR] INSECTICIDES A BASE D'ANTHRANILAMIDES

  摘要：

  公开号：

  WO2005118552A3

文献信息

• Anthranilamide insecticides
  申请人：Lahm Philip George

  公开号：US20070184018A1

  公开（公告）日：2007-08-09

  This invention provides compounds of Formula (1), N oxides and suitable salts thereof, wherein R 1 is Me, Cl, Br or I; R 2 is Cl, Br, I or —CN; R 3 is Cl, Br, CF 3 , OCH 2 CF 3 or OCF 2 H; R 4 is H; or C 1-4 alkyl, C 2-4 alkenyl or C 2-4 alkynyl, each optionally substituted with CN or Sme; and R 5 is phenyl substituted with 1 to 3 substituents selected from the group consisting of F, Cl, Br and Me. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula (1), an N-oxide thereof or a suitable salt of the compound (e.g., as a composition described herein). This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula (1), an N-oxide thereof or a suitable salt of the compound and at least one additional component selected from the group consisting of a surfactant, a solid diluent and a liquid diluent.

  本发明提供了公式（1）的化合物，N氧化物以及适当的盐，其中R1为Me、Cl、Br或I；R2为Cl、Br、I或—CN；R3为Cl、Br、CF3、OCH2CF3或OCF2H；R4为H；或C1-4烷基、C2-4烯基或C2-4炔基，每个基团可选择性地被CN或Sme取代；R5为苯基，选自F、Cl、Br和Me的1至3个取代基。还公开了一种用公式（1）的化合物、其N-氧化物或化合物的适当盐（例如，如本文所述的组合物）的生物有效量接触无脊椎动物害虫或其环境以控制无脊椎动物害虫的方法。本发明还涉及一种控制无脊椎动物害虫的组合物，其包括公式（1）的化合物、其N-氧化物或化合物的适当盐的生物有效量，以及选自表面活性剂、固体稀释剂和液体稀释剂的至少一种额外成分。
• LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES
  申请人：Gutsche Oliver

  公开号：US20100055084A1

  公开（公告）日：2010-03-04

  Disclosed are suspension concentrate compositions comprising by weight based on the total weight of the composition, (a) from about 0.1 to about 50% of one or more carboxamide arthropodicides that are solid at room temperature; (b) from 0 to about 50% of one or more biologically active agents other than the carboxamide arthropodicides; (c) from about 20 to about 70% of water; (d) from about 10 to about 70% of one or more water-immiscible liquid compounds; and (e) from about 1 to about 55% of a surfactant component having a dispersing property. This invention also relates to a method for controlling an arthropod pest comprising diluting said suspension concentrate composition with water, optionally adding an adjuvant to form a diluted composition, and contacting the arthropod pest or its environment with an effective amount of said diluted composition.

  本发明涉及悬浮浓缩物组成物，其按总组成物重量计含有以下成分：(a)约0.1至约50%的一种或多种在室温下为固体的羧酰胺类节肢动物杀虫剂；(b)0至约50%的一种或多种除羧酰胺类节肢动物杀虫剂之外的生物活性剂；(c)约20至约70%的水；(d)约10至约70%的一种或多种不溶于水的液态化合物；以及(e)约1至约55%具有分散性质的表面活性剂成分。本发明还涉及一种控制节肢动物害虫的方法，包括将所述悬浮浓缩物组成物稀释于水中，可选地添加辅助剂以形成稀释后的组成物，并用所述稀释后的组成物与节肢动物害虫或其环境接触，以达到有效量的控制作用。
• Liquid Formulations of Carboxamide Arthropodicides
  申请人：Gutsche Oliver Walter

  公开号：US20080305093A1

  公开（公告）日：2008-12-11

  Disclosed are suspension concentrate compositions comprising by weight based on the total weight of the composition, about 0.1 to about 40% of at least one carboxamide arthropodicide; 0 to about 20% of at least one other biologically active agent; about 30 to about 95% of at least one water-immiscible liquid carrier; about 2 to about 50% of at least one emulsifier; about 0.01 to about 10% of a silica thickener; about 0.1 to about 10% of at least one protic solvent selected from water, a C 1 -C 12 alkanol and a C 2 -C 3 glycol; and about 0.001 to about 5% of at least one water-soluble carboxylic acid. This invention also relates to a method for controlling an arthropod pest comprising diluting said suspension concentrate composition with water, and optionally adding an adjuvant to form a diluted composition, and contacting the arthropod pest or its environment with an effective amount of said diluted composition.

  本发明涉及悬浮浓缩物组合物，其包括以下重量百分比，基于组合物的总重量：约0.1至约40％的至少一种羧酰胺类节肢动物杀虫剂；0至约20％的至少一种其他生物活性剂；约30至约95％的至少一种不溶于水的液体载体；约2至约50％的至少一种乳化剂；约0.01至约10％的二氧化硅增稠剂；约0.1至约10％的至少一种质子溶剂，所述质子溶剂选自水，C1-C12烷基醇和C2-C3二元醇；以及约0.001至约5％的至少一种水溶性羧酸。本发明还涉及一种控制节肢动物害虫的方法，包括将悬浮浓缩物组合物与水稀释，并可选地添加一种助剂以形成稀释后的组合物，并使用所述稀释后的组合物的有效量与节肢动物害虫或其环境接触。
• SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES
  申请人：Gutsche Oliver Walter

  公开号：US20110059846A1

  公开（公告）日：2011-03-10

  Disclosed is a solid arthropodicide composition comprising by weight (a) from 0.3 to 100% of a particulate component comprising particles of a solid carrier infiltrated with a mixture comprising (i) one or more carboxamide arthropodicides and (ii) a surfactant constituent; (b) from 0 to 50% of a surfactant component having dispersing and wetting properties; and (c) from 0 to 99.7% of one or more additional formulating ingredients. Also disclosed is a propagule contacted with a biologically effective amount of said composition.

  本发明公开了一种固体节肢动物杀虫剂组合物，其包括以下重量百分比的成分：（a）0.3至100％的颗粒组分，该颗粒组分包括被混合物浸渍的固体载体颗粒，所述混合物包括（i）一种或多种羧酰胺类节肢动物杀虫剂和（ii）一种表面活性剂成分；（b）具有分散和润湿性能的表面活性剂组分，其含量为0至50％；以及（c）0至99.7％的一种或多种额外的配方成分。本发明还公开了一种接触到所述组合物生物有效量的繁殖体。
• METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP2001300A2

  公开（公告）日：2008-12-17