3-(hydroxy(phenyl)methyl)-5-methylfuran-2(5H)-one | 1415357-12-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 3-(hydroxy(phenyl)methyl)-5-methylfuran-2(5H)-one
• 英文别名: 4-[hydroxy(phenyl)methyl]-2-methyl-2H-furan-5-one
• CAS: 1415357-12-8
• 化学式: C₁₂H₁₂O₃
• 分子量: 204.225
• InChiKey: BQJSOCQLDPNXKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-甲基-2(5H)-呋喃酮 、 苯甲醛 、 phenylselenomagnesium bromide 在 双氧水 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以0.4533 g的产率得到3-(hydroxy(phenyl)methyl)-5-methylfuran-2(5H)-one
  参考文献：
  名称：

  Metallic chalcogenolates mediated modular Michael-aldol cascade reaction: an easy route to multi-functionalized chalcogenides and Morita–Baylis–Hillman adducts

  摘要：

  Chalcogenolate mediated Michael-aldol cascade reactions consists of a very efficient route to multi-functionalized gamma-hydroxichalcogenides. Although, when selenolates are employed, these gamma-hydroxichalcogenides can be readily converted into the corresponding Morita-Baylis-Hillman adducts by oxidative elimination of the selenium moiety. In this context, herein we present a complete study on the scope and limitations of this reaction. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.09.027

文献信息

• Metallic chalcogenolates mediated modular Michael-aldol cascade reaction: an easy route to multi-functionalized chalcogenides and Morita–Baylis–Hillman adducts
  作者：Bruno A. Sousa、Arthur F. Keppler、Rogério A. Gariani、João V. Comasseto、Alcindo A. Dos Santos

  DOI：10.1016/j.tet.2012.09.027

  日期：2012.12

  Chalcogenolate mediated Michael-aldol cascade reactions consists of a very efficient route to multi-functionalized gamma-hydroxichalcogenides. Although, when selenolates are employed, these gamma-hydroxichalcogenides can be readily converted into the corresponding Morita-Baylis-Hillman adducts by oxidative elimination of the selenium moiety. In this context, herein we present a complete study on the scope and limitations of this reaction. (C) 2012 Elsevier Ltd. All rights reserved.