4-nitro-N-[4-(6-methylbenzothiazol-2-yl)phenyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-nitro-N-[4-(6-methylbenzothiazol-2-yl)phenyl]benzamide
• 英文别名: 4-nitro-benzoic acid-[4-(6-methyl-benzothiazol-2-yl)-anilide]；4-Nitro-benzoesaeure-[4-(6-methyl-benzothiazol-2-yl)-anilid]；N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]-4-nitrobenzamide
• 化学式: C₂₁H₁₅N₃O₃S
• mdl: MFCD00350333
• 分子量: 389.434
• InChiKey: XFNXFWJNBPHHBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  、 1,2-Dichloroethane 2-(4-aminophenyl)-6-methylbenzothiazole 、 4-硝基苯甲酰氯 以 吡啶 为溶剂， 以to give the title compound (4.0 g, 99%) as small tan-coloured needles的产率得到4-nitro-N-[4-(6-methylbenzothiazol-2-yl)phenyl]benzamide
  参考文献：
  名称：

  Ligands for aggregated tau molecules

  摘要：

  提供了某些苯并噻唑、咪唑噻唑、咪唑嘧啶和咪唑吡啶化合物，包括例如：式（I）和其药学和生理学上可接受的盐、水合物和溶剂化物。这些化合物可用作tau蛋白和PHF的诊断配体或标记物。

  公开号：

  US08895313B2

文献信息

• LIGANDS FOR AGGREGATED TAU MOLECULES
  申请人：Kemp Steven John

  公开号：US20110171739A1

  公开（公告）日：2011-07-14

  Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.

  提供了某些苯并噻唑、咪唑噻唑、咪唑嘧啶和咪唑吡啶化合物，包括例如：式（I）和其药学和生理学上可接受的盐、水合物和溶剂化物。这些化合物可用作tau蛋白和PHF的诊断配体或标记。
• Treatment and Prevention of Dengue Virus Infections
  申请人：Byrd Chelsea M.

  公开号：US20120258079A1

  公开（公告）日：2012-10-11

  Methods and pharmaceutical compositions for treating viral infections, by administering certain 2 -aryl-benzothiazole or 2 -heteroaryl-benzothiazole derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
• US8895313B2
  申请人：——

  公开号：US8895313B2

  公开（公告）日：2014-11-25
• US8993604B2
  申请人：——

  公开号：US8993604B2

  公开（公告）日：2015-03-31
• [EN] LIGANDS FOR AGGREGATED TAU MOLECULES<br/>[FR] LIGANDS POUR MOLÉCULES DE LA PROTÉINE TAU AGGLOMÉRÉES
  申请人：WISTA LAB LTD

  公开号：WO2010034982A1

  公开（公告）日：2010-04-01

  Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example:formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.