(6-Oxobenzo[c]chromen-3-yl) 4-(4-ethylphenoxy)butanoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: (6-Oxobenzo[c]chromen-3-yl) 4-(4-ethylphenoxy)butanoate
• 化学式: C₂₅H₂₂O₅
• 分子量: 402.4
• InChiKey: PMKDKXCKHUOEOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Sirtuin modulators as inhibitors of cytomegalovirus
  申请人：The Trustees of Princeton University

  公开号：US10813934B2

  公开（公告）日：2020-10-27

  Agents and methods of inhibiting or improving the growth of viruses are provided.

  提供了抑制或改善病毒生长的制剂和方法。
• Method for identifying a compound that modulates SIR2 protein activity
  申请人：Marmorstein Ronen

  公开号：US20080305496A1

  公开（公告）日：2008-12-11

  The present invention relates to a method for identifying compounds that modulate the activity of sirtuin deacetylase protein family members. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified nicotinamide inhibition and base exchange site of Sir2 and testing the compound for its ability to modulate the activity of the Sir2 protein. Compositions and methods for preventing or treating diseases or disorders associated with Sir2 are also provided.
• Compounds and methods for modulating sir2 protein activity
  申请人：Marmorstein Ronen

  公开号：US20090326007A1

  公开（公告）日：2009-12-31

  The present invention embraces compounds that modulate the activity of sirtuin deacetylase protein family members and use thereof for modulating Sir2 activity as well as for preventing or treating diseases or disorders associated with Sir2.
• Sirtuin Modulators as Inhibitors of Cytomegalovirus
  申请人：The Trustees of Princeton University

  公开号：US20160296523A1

  公开（公告）日：2016-10-13

  Agents and methods of inhibiting or improving the growth of viruses are provided.
• US8180580B2
  申请人：——

  公开号：US8180580B2

  公开（公告）日：2012-05-15