7-(4-fluorophenyl)-1-(2-furylmethyl)-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 7-(4-fluorophenyl)-1-(2-furylmethyl)-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
• 英文别名: 7-(4-fluorophenyl)-1-(furan-2-ylmethyl)-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione
• 化学式: C₁₉H₁₁F₇N₄O₃
• mdl: MFCD03941075
• 分子量: 476.3
• InChiKey: VUPUMPIRRCKDTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  86.9
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• METHOD FOR REGULATING SKIN PIGMENTATION
  申请人：Fisher David E.

  公开号：US20140296223A1

  公开（公告）日：2014-10-02

  This invention relates to a method for regulating skin pigmentation of a subject, comprising the step of administering the agent for inhibiting the expression or activation of Microphthalmia Transcription Factor (MITF) to the subject who is in need of regulation of skin pigmentation.
• [EN] A METHOD FOR REGULATING SKIN PIGMENTATION<br/>[FR] PROCÉDÉ DE RÉGULATION DE LA PIGMENTATION DE LA PEAU
  申请人：GEN HOSPITAL CORP

  公开号：WO2013033520A1

  公开（公告）日：2013-03-07

  This invention relates to a method for regulating skin pigmentation of a subject, comprising the step of administering the agent for inhibiting the expression or activation of Microphthalmia Transcription Factor (MITF) to the subject who is in need of regulation of skin pigmentation.