1,2-bis(2-(pyridin-2-ylthio)ethoxy)ethane | 501935-17-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1,2-bis(2-(pyridin-2-ylthio)ethoxy)ethane
• 英文别名: bis(2-(pyridin-2-ylthio)ethoxy)ethane；2-[2-[2-(2-Pyridin-2-ylsulfanylethoxy)ethoxy]ethylsulfanyl]pyridine
• CAS: 501935-17-7
• 化学式: C₁₆H₂₀N₂O₂S₂
• 分子量: 336.479
• InChiKey: DROIIVZSWPIUHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  94.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,2-bis(2-(pyridin-2-ylthio)ethoxy)ethane 、 silver nitrate 以 甲醇 、 氯仿 为溶剂， 以50.5%的产率得到(bis(2-(pyridin-2-ylthio)ethoxy)ethane)dinitrodisilver(I)
  参考文献：
  名称：

  Syntheses, structures and bioactivities of silver(I) complexes with dithioether ligands that contain a di- or triethylene glycol chain and different terminal groups

  摘要：

  A series of flexible dithioethyl ligands that contain ethyleneoxy segments were designed and synthesized, including bis(2-(pyridin-2-ylthio)ethyl) ether (L-1), 1,2-bis(2-(pyridin-2-ylthio) ethoxy) ethane (L-2), bis (2-(benzothiazol-2-ylthio) ethyl) ether (L-3) and 1,2-bis(2-(benzothiazol-2-ylthio) ethoxy) ethane (L-4). Reactions of these ligands with AgNO3 led to the formation of four new supramolecular coordination complexes, [Ag2L1(NO3)(2)](2) (1), [Ag2L2(NO3)(2)] (2), [AgL3(NO3)](infinity) (3) and [AgL4(NO3)] (4) in which the length of the (CH2CH2O)(n) spacers and the terminal groups of ligands cause subtle geometrical differences. Studies of the inhibitory effect to the growth of Phaeodactylum tricornutum show that all four complexes are active and the compound 4 has the highest inhibitory activity. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.06.026
• 作为产物：
  描述：

  2-巯基吡啶 、 1,2-二(2-氯乙氧基)乙烷 在 potassium hydroxide 作用下， 以 乙醇 为溶剂， 以59.5%的产率得到1,2-bis(2-(pyridin-2-ylthio)ethoxy)ethane
  参考文献：
  名称：

  Syntheses, structures and bioactivities of silver(I) complexes with dithioether ligands that contain a di- or triethylene glycol chain and different terminal groups

  摘要：

  A series of flexible dithioethyl ligands that contain ethyleneoxy segments were designed and synthesized, including bis(2-(pyridin-2-ylthio)ethyl) ether (L-1), 1,2-bis(2-(pyridin-2-ylthio) ethoxy) ethane (L-2), bis (2-(benzothiazol-2-ylthio) ethyl) ether (L-3) and 1,2-bis(2-(benzothiazol-2-ylthio) ethoxy) ethane (L-4). Reactions of these ligands with AgNO3 led to the formation of four new supramolecular coordination complexes, [Ag2L1(NO3)(2)](2) (1), [Ag2L2(NO3)(2)] (2), [AgL3(NO3)](infinity) (3) and [AgL4(NO3)] (4) in which the length of the (CH2CH2O)(n) spacers and the terminal groups of ligands cause subtle geometrical differences. Studies of the inhibitory effect to the growth of Phaeodactylum tricornutum show that all four complexes are active and the compound 4 has the highest inhibitory activity. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.06.026