[[(E)-3-phenylprop-2-enoxy]carbonylamino] 2,4-dichlorobenzoate | 1424055-83-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [[(E)-3-phenylprop-2-enoxy]carbonylamino] 2,4-dichlorobenzoate
• CAS: 1424055-83-3
• 化学式: C₁₇H₁₃Cl₂NO₄
• 分子量: 366.201
• InChiKey: ZWXQJTGXKDZHME-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [[(E)-3-phenylprop-2-enoxy]carbonylamino] 2,4-dichlorobenzoate 在 iron(II) bis((trifluoromethyl)sulfonyl)amide 、 (4S,4'S,5R,5'R)-2,2'-(propane-2,2-diyl)bis(4,5-diphenyl-4,5-dihydrooxazole) 、 偶氮二甲酸二异丙酯 、 三苯基膦 、 lithium hydroxide 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 14.0h， 生成 (2-oxooxazolidin-4-yl)(phenyl)methyl 2,4-dichlorobenzoate
  参考文献：
  名称：

  Iron(II)-Catalyzed Intramolecular Aminohydroxylation of Olefins with Functionalized Hydroxylamines

  摘要：

  A diastereoselective aminohydroxylation of olefins with a functionalized hydroxylamine is catalyzed by new iron(II) complexes. This efficient intramolecular process readily affords synthetically useful amino alcohols with excellent selectivity (dr up to > 20:1). Asymmetric catalysis with chiral iron(II) complexes and preliminary mechanistic studies reveal an iron nitrenoid is a possible intermediate that can undergo either aminohydroxylation or aziridination, and the selectivity can be controlled by careful selection of counteranion/ligand combinations.

  DOI：

  10.1021/ja311923z

文献信息

• Iron(II)-Catalyzed Intramolecular Aminohydroxylation of Olefins with Functionalized Hydroxylamines
  作者：Guan-Sai Liu、Yong-Qiang Zhang、Yong-An Yuan、Hao Xu

  DOI：10.1021/ja311923z

  日期：2013.3.6

  A diastereoselective aminohydroxylation of olefins with a functionalized hydroxylamine is catalyzed by new iron(II) complexes. This efficient intramolecular process readily affords synthetically useful amino alcohols with excellent selectivity (dr up to > 20:1). Asymmetric catalysis with chiral iron(II) complexes and preliminary mechanistic studies reveal an iron nitrenoid is a possible intermediate that can undergo either aminohydroxylation or aziridination, and the selectivity can be controlled by careful selection of counteranion/ligand combinations.