N-(3-N'-morpholino-1-propyl)-1,8-naphthalimide | 107107-81-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-(3-N'-morpholino-1-propyl)-1,8-naphthalimide
• 英文别名: 2-(3-morpholin-4-yl-propyl]-benzo[de]isoquinoline-1,3-dione；2-[3-(morpholin-4-yl)propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione；2-(3-morpholin-4-ylpropyl)benzo[de]isoquinoline-1,3-dione
• CAS: 107107-81-3
• 化学式: C₁₉H₂₀N₂O₃
• mdl: MFCD00181333
• 分子量: 324.379
• InChiKey: GQPIEFFYGONFTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(3-氨丙基)吗啉 、 1,8-萘二甲酸酐 以 乙醇 为溶剂， 反应 2.0h， 以85%的产率得到N-(3-N'-morpholino-1-propyl)-1,8-naphthalimide
  参考文献：
  名称：

  Synthesis and fluorescence ofN-substituted-1,8-naphthalimides

  摘要：

  AbstractA number of novel N‐substituted‐1,8‐naphthalimides have been prepared and their fluorescence yields measured in water at pH 7.4. The type of substitutent and the substitution pattern on the naphthalimide nucleus produce markedly different fluorescence yields, (quantum efficiencies, ø varying from ø = 0‐0037 for N‐(3‐N'‐morpholino‐1‐propyl)‐4‐amino‐3‐methoxy‐1,8‐naphthalirnide (7) to ø = 0–77 for N‐(3‐bromopropyl)‐4‐acetamido‐1,8‐naphthalimide (31).

  DOI：

  10.1002/jhet.5570230337

文献信息

• Compositions and methods for modulating interaction between polypeptides
  申请人：Kazantsev G. Aleksey

  公开号：US20050239833A1

  公开（公告）日：2005-10-27

  The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.

  本发明部分基于我们所进行的检测，这些检测揭示了可用于治疗或预防以一种蛋白质与另一种蛋白质的异常或不良结合为特征的疾病的化合物。
• COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES
  申请人：The General Hospital Corporation

  公开号：US20130203733A1

  公开（公告）日：2013-08-08

  The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.
• US8404747B2
  申请人：——

  公开号：US8404747B2

  公开（公告）日：2013-03-26
• [EN] COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES<br/>[FR] COMPOSITIONS ET PROCEDES POUR MODULER L'INTERACTION ENTRE DES POLYPEPTIDES
  申请人：GEN HOSPITAL CORP

  公开号：WO2005087217A1

  公开（公告）日：2005-09-22

  The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.
• Synthesis and fluorescence of<i>N</i>-substituted-1,8-naphthalimides
  作者：Richard W. Middleton、John Parrick、Eric D. Clarke、Peter Wardman

  DOI：10.1002/jhet.5570230337

  日期：1986.5

  AbstractA number of novel N‐substituted‐1,8‐naphthalimides have been prepared and their fluorescence yields measured in water at pH 7.4. The type of substitutent and the substitution pattern on the naphthalimide nucleus produce markedly different fluorescence yields, (quantum efficiencies, ø varying from ø = 0‐0037 for N‐(3‐N'‐morpholino‐1‐propyl)‐4‐amino‐3‐methoxy‐1,8‐naphthalirnide (7) to ø = 0–77 for N‐(3‐bromopropyl)‐4‐acetamido‐1,8‐naphthalimide (31).