N-[3-(diethylamino)propyl]-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[3-(diethylamino)propyl]-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
• 化学式: C₂₂H₂₆F₃N₅O
• mdl: MFCD01529387
• 分子量: 433.5
• InChiKey: DVAPYEJBWGEAJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  62.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Small Molecule Inhibitors of Mrp1 and Other Multidrug Transporters
  申请人：Gudkov Andrei

  公开号：US20080032966A1

  公开（公告）日：2008-02-07

  A method of potentiating the activity of a therapeutic drug, like a chemotherapeutic drug or an antibiotic, in a cell or tissue, by inhibiting the efflux capability of a multidrug transporter are disclosed. The method is useful in the treatment of a cancer by sensitizing tumor cells to a chemotherapeutic agent. Compounds capable of inhibiting an efflux capability of a multidrug transporter also are disclosed.
• US8318724B2
  申请人：——

  公开号：US8318724B2

  公开（公告）日：2012-11-27