cyclopropylcarbamoyl chloride | 652131-62-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cyclopropylcarbamoyl chloride
• 英文别名: cyclopropylcarbamic chloride；N-Cyclopropylcarbamoyl chloride
• CAS: 652131-62-9
• 化学式: C₄H₆ClNO
• mdl: MFCD19227610
• 分子量: 119.551
• InChiKey: IPESDCXPCKZBKR-UHFFFAOYSA-N

物化性质

• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  cyclopropylcarbamoyl chloride 、 2-甲基-2-丙基2-丙基肼羧酸酯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 tert-butyl 2-(cyclopropylcarbamoyl)-2-propylhydrazine-1-carboxylate
  参考文献：
  名称：

  Potent aza-peptide derived inhibitors of HCV NS3 protease

  摘要：

  Chronic hepatitis C infection is the primary cause for cirrhosis of the liver and hepatocellular carcinoma leading to liver failure and transplantation. The etiological agent hepatitis C virus produces a single positive strand RNA that is processed further with the help of NS3 serine protease to produce mature virus. Inhibition of this protease can potentially be used to develop drugs for HCV infections. Boceprevir is a ketoamide derived novel inhibitor of HCV NS3 protease that has been progressed to clinical trials and proven to be efficacious in humans. Herein, we report our efforts in identifying an aza-peptide derivative as a potential second generation compound, that lacks electrophilic ketoamide group and are potent in enzyme and replicon assay. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2009.06.060

文献信息

• Synthesis and SAR studies of 3,6-disubstituted indazole derivatives as potent hepcidin production inhibitors
  作者：Takeshi Fukuda、Kenjiro Ueda、Takashi Ishiyama、Riki Goto、Sumie Muramatsu、Masami Hashimoto、Kengo Watanabe、Naoki Tanaka

  DOI：10.1016/j.bmcl.2017.03.056

  日期：2017.5

  hepcidin could be a strategy favorable to treating anemia of chronic disease (ACD). We report herein the synthesis and structure-activity relationships (SARs) of a series of indazole compounds as hepcidin production inhibitors. The optimization study of compound 1 led to a potent hepcidin production inhibitor 45, which showed serum hepcidin lowering effects in a mouse IL-6 induced acute inflammatory model

  铁调素已经成为系统性铁稳态的主要调节分子。抑制铁调素可能是一种有利于治疗慢性疾病性贫血（ACD）的策略。我们在此报告了一系列作为铁调素生产抑制剂的吲唑化合物的合成和构效关系（SAR）。化合物1的优化研究产生了有效的铁调素生成抑制剂45，该抑制剂在小鼠IL-6诱导的急性炎症模型中显示出血清铁调素降低的作用。
• [EN] CARBAMATE, ESTER, AND KETONE COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS<br/>[FR] COMPOSÉS CARBAMATE, ESTER, ET CÉTONE POUR LE TRAITEMENT DE TROUBLES IMMUNITAIRES ET INFLAMMATOIRES
  申请人：ACHILLION PHARMACEUTICALS INC

  公开号：WO2017035413A3

  公开（公告）日：2017-03-30
• Potent aza-peptide derived inhibitors of HCV NS3 protease
  作者：Srikanth Venkatraman、Wanli Wu、Neng-Yang Shih、F. George Njoroge

  DOI：10.1016/j.bmcl.2009.06.060

  日期：2009.8

  Chronic hepatitis C infection is the primary cause for cirrhosis of the liver and hepatocellular carcinoma leading to liver failure and transplantation. The etiological agent hepatitis C virus produces a single positive strand RNA that is processed further with the help of NS3 serine protease to produce mature virus. Inhibition of this protease can potentially be used to develop drugs for HCV infections. Boceprevir is a ketoamide derived novel inhibitor of HCV NS3 protease that has been progressed to clinical trials and proven to be efficacious in humans. Herein, we report our efforts in identifying an aza-peptide derivative as a potential second generation compound, that lacks electrophilic ketoamide group and are potent in enzyme and replicon assay. (C) 2009 Published by Elsevier Ltd.