5-溴-1,3-二甲基-6-苯基尿嘧啶 | 98854-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 5-溴-1,3-二甲基-6-苯基尿嘧啶
• 英文名称: 5-bromo-1,3-dimethyl-6-phenyluracil
• 英文别名: 5-bromo-1,3-dimethyl-6-phenylpyrimidine-2,4-dione
• CAS: 98854-09-2
• 化学式: C₁₂H₁₁BrN₂O₂
• 分子量: 295.136
• InChiKey: YZIYDIAFSLMSGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933599090

反应信息

• 作为产物：
  描述：

  5,6-二溴-1,3-二甲基嘧啶-2,4-二酮 、 苯 以45%的产率得到
  参考文献：
  名称：

  IKEHIRA, HIDEYUKI;MATSUURA, TERUO;SAITO, ISAO, TETRAHEDRON LETT., 1985, 26, N 14, 1743-1746

  摘要：

  DOI：

文献信息

• Pyrimidinones. 3. N-Substituted 6-phenylpyrimidinones and pyrimidinediones with diuretic/hypotensive and antiinflammatory activity
  作者：Harvey I. Skulnick、James H. Ludens、Michael G. Wendling、E. Myles Glenn、Norman A. Rohloff、Robert J. Smith、Wendell Wierenga

  DOI：10.1021/jm00158a030

  日期：1986.8

  In an extensive analysis of the antiviral and interferon-induction structure-activity relationship of 6-arylpyrimidinones we found that modifications at positions 1-4 of the pyrimidine ring resulted in a loss of activity. However, we uncovered interesting hypotensive and antiinflammatory activity with a series of N-substituted analogues, the results of which we report herein.
• Regioselective arylation of uracil and 4-pyridone derivatives via copper(I) bromide mediated C–H bond activation
  作者：Chien Cheng、Yu-Chiao Shih、Hui-Ting Chen、Tun-Cheng Chien

  DOI：10.1016/j.tet.2012.11.001

  日期：2013.1

  A facile and effective synthesis of 6-aryluracil derivatives was accomplished by the direct C H bond activation for arylation. A series of 6-aryl-1,3-dimethyluracils were synthesized from the reaction of 1,3-dimethyluracil with various phenyl iodides in DMF, in the presence of copper(I) bromide as the catalyst and lithium tert-butoxide as the base. This methodology is applicable to a variety of 5-substituted uracils as well as 4-pyridone to provide direct accesses to versatile uracil and 4-pyridone derivatives. (C) 2012 Elsevier Ltd. All rights reserved.
• Photochemistry of 6-halo- and 5,6-dihalouracils. A simple synthesis of fluorescent uracil derivatives
  作者：Hideyuki Ikehira、Teruo Matsuura、Isao Saito

  DOI：10.1016/s0040-4039(00)98327-8

  日期：1985.1
• SKULNICK H. I.; LUDENS J. H.; WENDLING M. G.; GLENN E. M.; ROHLOFF N. A.;+, J. MED. CHEM., 29,(1986) N 8, 1499-1504
  作者：SKULNICK H. I.、 LUDENS J. H.、 WENDLING M. G.、 GLENN E. M.、 ROHLOFF N. A.、+

  DOI：——

  日期：——
• US4593030A
  申请人：——

  公开号：US4593030A

  公开（公告）日：1986-06-03