phenethyl-(2-pyridin-4-ylquinazolin-4-yl)-amine | 361178-81-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: phenethyl-(2-pyridin-4-ylquinazolin-4-yl)-amine
• 英文别名: Phenethyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine；N-(2-phenylethyl)-2-pyridin-4-ylquinazolin-4-amine
• CAS: 361178-81-6
• 化学式: C₂₁H₁₈N₄
• 分子量: 326.401
• InChiKey: WPXDLZLLGWQSIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS<br/>[FR] PROCÉDÉS ET MATÉRIAUX POUR AUGMENTER LES NIVEAUX DE POLYPEPTIDES EB DE FACTEUR DE TRANSCRIPTION
  申请人：UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION

  公开号：WO2020142748A1

  公开（公告）日：2020-07-09

  This document provides methods and materials for increasing TFEB polypeptide levels. For example, compounds (e.g., organic compounds) having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for increasing TFEB polypeptide levels within cells and/or within a nucleus of cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in TFEB polypeptide levels are provided.