2-(2-chloro-4,5-dihydroxyphenyl)-N-[2-(5-methoxycyclohexa-1,4-dien-1-yl)ethyl]acetamide | 860461-51-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-chloro-4,5-dihydroxyphenyl)-N-[2-(5-methoxycyclohexa-1,4-dien-1-yl)ethyl]acetamide
• CAS: 860461-51-4
• 化学式: C₁₇H₂₀ClNO₄
• 分子量: 337.803
• InChiKey: BFEMGWLCLIRGSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(2-chloro-4,5-dihydroxyphenyl)-N-[2-(3-methoxyphenyl)ethyl]acetamide 在 乙醇 、 氨 、 sodium ethanolate 、 sodium 作用下， 生成 2-(2-chloro-4,5-dihydroxyphenyl)-N-[2-(5-methoxycyclohexa-1,4-dien-1-yl)ethyl]acetamide 、 2-(5-methoxy-cyclohexa-1,4-dienyl)-ethylamine
  参考文献：
  名称：

  [EN] METHOD FOR SELECTIVE REDUCTION OF AROMATIC COMPOUNDS
  [FR] PROCEDE DE REDUCTION SELECTIVE DE COMPOSES AROMATIQUES

  摘要：

  公开号：

  WO2005068403A3

文献信息

• METHOD FOR SELECTIVE REDUCTION OF AROMATIC COMPOUNDS
  申请人：MALLINCKRODT, INC.

  公开号：EP1718582B1

  公开（公告）日：2009-10-14
• Method for selective reduction of aromatic compounds
  申请人：Wang Xianqi Peter

  公开号：US20070112232A1

  公开（公告）日：2007-05-17

  A method for the selective reduction of an aromatic compound. The present invention provides a method for pre-venting the reduction of at least one halogen substituted aromatic ring of an aromatic compound, while allowing the reduction of at least one functional group on the aromatic compound. In the present invention at least one hydroxyl group is placed on the at least one halogen substituted aromatic ring to be protected from reduction. The aromatic compound is then reacted with at least one alkali metal in at least one nitrogen containing base and at least one alcohol at a ratio of the alcohol to the nitrogen containing base at which the aromatic ring with the hydroxyl group is protected from reduction, while the desired functional group is reduced.
• US7312368B2
  申请人：——

  公开号：US7312368B2

  公开（公告）日：2007-12-25
• [EN] METHOD FOR SELECTIVE REDUCTION OF AROMATIC COMPOUNDS<br/>[FR] PROCEDE DE REDUCTION SELECTIVE DE COMPOSES AROMATIQUES
  申请人：MALLINCKRODT INC

  公开号：WO2005068403A3

  公开（公告）日：2005-09-01