1-(furan-2-yl)-N-(2-phenylethyl)methanimine | 69819-53-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(furan-2-yl)-N-(2-phenylethyl)methanimine
• 英文别名: furfural-phenethylimine；Furfural-phenaethylimin
• CAS: 69819-53-0
• 化学式: C₁₃H₁₃NO
• 分子量: 199.252
• InChiKey: ANAVOAVCCMJUHE-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.94
• 重原子数：
  15.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  25.5
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  1-(furan-2-yl)-N-(2-phenylethyl)methanimine 在 甲醇 、 铂 作用下， 生成 呋喃-2-甲基-苯乙胺
  参考文献：
  名称：

  与吲哚生物碱有关的合成实验

  摘要：

  DOI：

  10.1039/jr9550002675
• 作为产物：
  描述：

  2-苯乙胺 、 糠醛 在 [bmim]PF₆ 、 4 A molecular sieve 作用下， 反应 2.0h， 生成 1-(furan-2-yl)-N-(2-phenylethyl)methanimine
  参考文献：
  名称：

  Molecular Sieves in Ionic Liquids as an Efficient and Recyclable Medium for the Synthesis of Imines

  摘要：

  多种亚胺得以高效地从醛和胺在离子液体中的反应中高产率地分离出来。这些离子液体可被回收并在至少五个循环中重复使用，而产率无明显下降，这为常用的反应溶剂二氯甲烷或乙醚提供了一个有用的替代选择。

  DOI：

  10.1055/s-2004-831328

文献信息

• Preparations of Secondary Amines and .beta.-Amino Esters via Additions of Grignard and Reformatsky Reagents to Imines and by One-Pot Reactions of Primary Amines, Aldehydes, and Grignards
  作者：Alan R. Katritzky、Qingmei Hong、Zhijun Yang

  DOI：10.1021/jo00116a027

  日期：1995.6

  Additions oi. Grignard and Reformatsky reagents to imines in the presence of 1-(trimethylsilyl)benzotriazole afforded in good yields the corresponding secondary amines and p-amino esters. The procedure is general as imines containing hydrogens a to both carbon and nitrogen can be employed. Extensions of this method to include imines containing other Lewis basic centers, e.g., those derived from furan-, thiophene-, indole-, and p-methoxybenzenecarboxaldehyde, have been successful in avoiding the potential complications which could result from the use of a Lewis acid as the activating : species. The imines need not be isolated, and a one-pot method for the synthesis of secondary amines from aldehydes, primary amines, and Grignard reagents is described.
• Katritzky Alan R., Hong Qingmei, Yang Zhijun, J. Org. Chem, 60 (1995) N 11, S 3405-3408
  作者：Katritzky Alan R., Hong Qingmei, Yang Zhijun

  DOI：——

  日期：——
• Molecular Sieves in Ionic Liquids as an Efficient and Recyclable Medium for the Synthesis of Imines
  作者：Carlos Kleber Andrade、Paulo Anselmo Suarez、Sayuri Cristina Takada、Luana Magalhães Alves、Juliana Petrocchi Rodrigues、Rodrigo Fleury Brandão、Valério Cassiano Soares

  DOI：10.1055/s-2004-831328

  日期：——

  A great variety of imines were efficiently isolated in high yields from the reaction of aldehydes and amines in ionic liquids. The ionic liquids could be recovered and reused for at least five cycles without loss in the yields being a useful alternative to dichloromethane or diethyl ether, which are the commonly used solvents for this reaction.

  多种亚胺得以高效地从醛和胺在离子液体中的反应中高产率地分离出来。这些离子液体可被回收并在至少五个循环中重复使用，而产率无明显下降，这为常用的反应溶剂二氯甲烷或乙醚提供了一个有用的替代选择。
• Synthetical experiments related to the indole alkaloids
  作者：K. T. Potts、Robert Robinson

  DOI：10.1039/jr9550002675

  日期：——