N-(1-phenylbut-3-en-1-yl)cyclododecanamine | 1268381-17-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(1-phenylbut-3-en-1-yl)cyclododecanamine
• 英文别名: N-(1-phenylbut-3-enyl)cyclododecanamine
• CAS: 1268381-17-4
• 化学式: C₂₂H₃₅N
• 分子量: 313.527
• InChiKey: RPPJFXXFMUXTBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Benzylaminocyclododecane 在 六甲基磷酰三胺 、 N-氯代丁二酰亚胺 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 3.75h， 生成 N-(1-phenylbut-3-en-1-yl)cyclododecanamine
  参考文献：
  名称：

  Preparation of 2-azaallyl anions and imines from N-chloroamines and their cycloaddition and allylation

  摘要：

  Exposure of N-chloroamines to (KOBu)-Bu-t or LDA, in the presence of PMDETA or HMPA, provides 2-azaallyl anions capable of pi 4s + pi 2s cycloaddition reactions with a range of olefins. Good yields were achieved with stabilised systems, however, they were more modest when accessing semi-stabilised 2-azaallyl anions. By modifying the reaction conditions, one-pot dehydrochlorination/allylation can also be achieved with a range of N-chloroamines. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2010.11.142

文献信息

• Preparation of 2-azaallyl anions and imines from N-chloroamines and their cycloaddition and allylation
  作者：Shveta Pandiancherri、David W. Lupton

  DOI：10.1016/j.tetlet.2010.11.142

  日期：2011.2

  Exposure of N-chloroamines to (KOBu)-Bu-t or LDA, in the presence of PMDETA or HMPA, provides 2-azaallyl anions capable of pi 4s + pi 2s cycloaddition reactions with a range of olefins. Good yields were achieved with stabilised systems, however, they were more modest when accessing semi-stabilised 2-azaallyl anions. By modifying the reaction conditions, one-pot dehydrochlorination/allylation can also be achieved with a range of N-chloroamines. (C) 2010 Published by Elsevier Ltd.