4-ethyl-N-[4-(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-ethyl-N-[4-(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]benzenesulfonamide
• 化学式: C₂₁H₂₀N₄O₂S
• 分子量: 392.5
• InChiKey: POKOVAWTRPARCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  96.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
  申请人：PLEXXIKON INC.

  公开号：US20140128390A1

  公开（公告）日：2014-05-08

  Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and mutant c-kit protein kinases.

  本文描述了对c-kit蛋白激酶或携带任何突变的突变c-kit蛋白激酶起作用的化合物，以及制备和使用这种化合物治疗与c-kit蛋白激酶和突变c-kit蛋白激酶的异常活性相关的疾病和病状的方法。
• Compounds and methods for kinase modulation, and indications therefor
  申请人：Plexxikon Inc.

  公开号：US10227357B2

  公开（公告）日：2019-03-12

  Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and mutant c-kit protein kinases.

  本文描述了对具有任何突变的 c-kit 蛋白激酶或突变 c-kit 蛋白激酶具有活性的化合物，以及制造和使用此类化合物治疗与 c-kit 蛋白激酶和突变 c-kit 蛋白激酶异常活性相关的疾病和病症的方法。
• DENDRITIC POLYMERS AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT EMPLOYING THE SAME
  申请人：RESEARCH INSITUTE INDUSTRIAL TECHNOLOGY

  公开号：US20130030139A1

  公开（公告）日：2013-01-31

  A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of SP-DZ-L) i ) j or SP-DX—Z-L) i ) j , wherein, S is cyclosilane moiety with j silicon oxygen residual groups, and j is not less than 2; P is CH 2 CH 2 O l , and l is not less than 1; D is a C 3-30 dendritic moiety having n oxygen residue, and n is not less than 3; X is C 3-30 moiety having bi-functional groups; Z is a C 3-20 moiety having a plurality of functional group; and L is a metal cation.
• [EN] COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR LA MODULATION DES KINASES, ET LEURS INDICATIONS
  申请人：PLEXXIKON INC

  公开号：WO2014039714A2

  公开（公告）日：2014-03-13

  Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and mutant c-kit protein kinases.