3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
• 化学式: C12H16Cl2N14O2
• 分子量: 459.3
• InChiKey: LMBGRGFGUMSLLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.58
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  319
• 氢给体数：
  8
• 氢受体数：
  10

文献信息

• NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE
  申请人：Pharnext

  公开号：EP2892518A2

  公开（公告）日：2015-07-15
• [EN] NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE<br/>[FR] NOUVELLES APPROCHES THÉRAPEUTIQUES POUR LE TRAITEMENT DE LA MALADIE DE PARKINSON
  申请人：PHARNEXT

  公开号：WO2014037416A2

  公开（公告）日：2014-03-13

  The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha- synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.