2,4-dihydroxy-5-propylbenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dihydroxy-5-propylbenzoic acid
• 英文别名: 2,4-Dihydroxy-5-propyl-benzoesaeure；2,4-Dihydroxy-5-propylbenzoic acid
• 化学式: C₁₀H₁₂O₄
• 分子量: 196.203
• InChiKey: OUFLIZDXHXEVEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4-dihydroxy-5-propylbenzoic acid 、 tert-butyl 4-(isoindolin-5-ylmethyl)piperazine-1-carboxylate 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以21%的产率得到tert-butyl 4-((2-(2,4-dihydroxy-5-propylbenzoyl)isoindolin-5-yl)methyl)piperazine-1-carboxylate
  参考文献：
  名称：

  [EN] METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION
  [FR] PROCÉDÉS ET COMPOSITIONS POUR UNE DÉGRADATION DE PROTÉINE CIBLÉE

  摘要：

  本文提供了用于靶向蛋白质降解的方法和组合物。在一个方面，提供了一种蛋白质降解嵌合体，包括：能够结合到辅助蛋白复合物成分的第一部分；能够结合到目标蛋白质的第二部分，其中目标蛋白质被靶向降解；以及用于共价耦合第一部分和第二部分的连接物。

  公开号：

  WO2020207396A1

文献信息

• CHARGE CONTROL RESIN AND MANUFACTURING METHOD OF THE SAME
  申请人：YASUMATSU Masashi

  公开号：US20150025213A1

  公开（公告）日：2015-01-22

  Here is provided a charge control resin which is prompt in charge rising up, excellent in electrostatic charging propensity and easy in manufacturing. This charge control resin contains a polymer as an active ingredient having a constituent unit represented by following Formula (1) in the Formula (1), R 1 is independent of one another, and is a hydrogen atom, a hydroxyl group, a halogen atom, a carboxy-containing group, a straight-chained or branched alkyl group having 1-18 carbon atoms, or a straight-chained or branched alkoxy group having 1-18 carbon atoms; R 2 is a hydrogen atom, a hydroxyl group, a halogen atom, a carboxy-containing group, a straight-chained or branched alkyl group having 1-18 carbon atoms, or a straight-chained or branched alkoxy group having 1-18 carbon atoms; g is a number of 1-3; h is a number of 1-3; and M is a hydrogen atom, an alkali metal, a straight-chained or branched alkyl group having 1-18 carbon atoms, an ammonium radical or a mixture of any of these.

  这里提供了一种电荷控制树脂，它在电荷上升方面快速，具有优异的静电充电倾向并且易于制造。该电荷控制树脂包含一种聚合物作为活性成分，该聚合物具有由以下公式（1）表示的组成单元。在公式（1）中，R1互不相同，可以是氢原子、羟基、卤素原子、含羧基的基团、直链或支链烷基（碳数为1-18）或直链或支链烷氧基（碳数为1-18）；R2可以是氢原子、羟基、卤素原子、含羧基的基团、直链或支链烷基（碳数为1-18）或直链或支链烷氧基（碳数为1-18）；g为1-3的数字；h为1-3的数字；M可以是氢原子、碱金属、直链或支链烷基（碳数为1-18）、铵基或任何这些的混合物。
• METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION
  申请人：Ranok Therapeutics (Hangzhou) Co. Ltd.

  公开号：US20220168427A1

  公开（公告）日：2022-06-02

  Provided herein are methods and compositions for targeted protein degradation. In one aspect, a protein degradation chimera is provided, comprising: a first moiety that is capable of binding to a chaperone complex component; a second moiety that is capable of binding to a target protein or proteins, wherein the target protein (s) is targeted for degradation; and a tether configured to covalently couple the first moiety and the second moiety.
• US8883946B2
  申请人：——

  公开号：US8883946B2

  公开（公告）日：2014-11-11
• US9079989B2
  申请人：——

  公开号：US9079989B2

  公开（公告）日：2015-07-14
• [EN] DYE COMPOSITION COMPRISING A RESORCINOL-BASED COUPLER AND AN OXIDATION BASE<br/>[FR] COMPOSITION COLORANTE COMPRENANT UN COUPLEUR À BASE DE RÉSORCINOL ET UNE BASE D'OXYDATION
  申请人：OREAL

  公开号：WO2017051020A1

  公开（公告）日：2017-03-30

  The present invention relates to a composition for dyeing keratin fibres, comprising one or more resorcinol-based couplers, one or more oxidation bases and, preferably, one or more oxidizing agents, preferably chemical oxidizing agents, said composition being free of catalyst, in particular free of metal catalyst. The present invention also relates to a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, using said composition, and also to a multi-compartment device that is suitable for using said composition.