4-(4-benzyl-3,5-dimethoxyphenyl)-6-(4-(4-methylpiperazin-1-yl)phenyl)-9H-pyrido[2,3-b]indole

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 4-(4-benzyl-3,5-dimethoxyphenyl)-6-(4-(4-methylpiperazin-1-yl)phenyl)-9H-pyrido[2,3-b]indole
• 英文别名: 4-(4-benzyl-3,5-dimethoxyphenyl)-6-[4-(4-methylpiperazin-1-yl)phenyl]-9H-pyrido[2,3-b]indole
• 化学式: C₃₇H₃₆N₄O₂
• 分子量: 568.718
• InChiKey: AETGECVEVXOBDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  43
• 可旋转键数：
  7
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  53.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] ALPHA-CARBOLINES FOR THE TREATMENT OF CANCER<br/>[FR] ALPHA-CARBOLINES POUR LE TRAITEMENT DU CANCER
  申请人：UNIV MILANO BICOCCA

  公开号：WO2013167730A1

  公开（公告）日：2013-11-14

  The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof, as well as to key intermediates towards their synthesis. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.

  本发明涉及如下式（I）所述的致癌蛋白激酶ALK的抑制剂及其药物组合物，以及用于其合成的关键中间体。式（I）的化合物在制备药物中具有用途，特别是用于癌症治疗。
• ALPHA-CARBOLINES FOR THE TREATMENT OF CANCER
  申请人：UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA

  公开号：US20150105554A1

  公开（公告）日：2015-04-16

  The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof, as well as to key intermediates towards their synthesis. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.

  本发明涉及公式（I）所述的癌基蛋白激酶ALK的抑制剂及其制药组合物，以及其合成的关键中间体。公式（I）化合物在制备药物中特别是用于癌症治疗方面具有用途。
• US9428500B2
  申请人：——

  公开号：US9428500B2

  公开（公告）日：2016-08-30