1-Methyl-6-phenylbenzimidazol-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-Methyl-6-phenylbenzimidazol-2-amine
• 英文别名: 1-methyl-6-phenylbenzimidazol-2-amine
• 化学式: C₁₄H₁₃N₃
• 分子量: 223.27
• InChiKey: KXMCAEIHZMEXHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PROTEIN EXPRESSION ANALYSES FOR IDENTIFYING GENOTOXIC COMPOUNDS
  申请人：Merck Patent GmbH

  公开号：EP2861985A1

  公开（公告）日：2015-04-22
• Protein expression analyses for identifying genotoxic compounds
  申请人：Merck Patent GmbH

  公开号：US20150140123A1

  公开（公告）日：2015-05-21

  The invention relates to a method for screening compounds with (pro-)genotoxic activity by providing a system being capable of expressing a panel of defined proteins, incubating at least a portion of the system with compounds to be screened, and comparing the expression of the proteins in the system with the protein expression in a control system, thereby detecting the (pro-)genotoxic activity. Another object of the invention concerns a method for monitoring the likelihood of developing a physiological and/or pathological condition, which is caused, mediated and/or propagated by the genetic deregulation of proliferation, differentiation and/or damage repair, in response to a compound administered to a mammal in need of such treatment by determining an expression level of defined proteins in a biological sample withdrawn from the mammal. The invention also relates to a kit for screening compounds with (pro-)genotoxic activity comprising antibodies that specifically bind to marker proteins.
• [EN] PROTEIN EXPRESSION ANALYSES FOR IDENTIFYING GENOTOXIC COMPOUNDS<br/>[FR] ANALYSES DE L'EXPRESSION DE PROTÉINES POUR L'IDENTIFICATION DE COMPOSÉS GÉNOTOXIQUES
  申请人：MERCK PATENT GMBH

  公开号：WO2013185884A1

  公开（公告）日：2013-12-19

  The invention relates to a method for screening compounds with (pro-)genotoxic activity by providing a system being capable of expressing a panel of defined proteins, incubating at least a portion of the system with compounds to be screened, and comparing the expression of the proteins in the system with the protein expression in a control system, thereby detecting the (pro-)genotoxic activity. Another object of the invention concerns a method for monitoring the likelihood of developing a physiological and/or pathological condition, which is caused, mediated and/or propagated by the genetic deregulation of proliferation, differentiation and/or damage repair, in response to a compound administered to a mammal in need of such treatment by determining an expression level of defined proteins in a biological sample withdrawn from the mammal. The invention also relates to a kit for screening compounds with (pro-)genotoxic activity comprising antibodies that specifically bind to marker proteins.