[(4R,7aR,12bS)-4a-hydroxy-3-methyl-7-oxo-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl] 2,2,2-trifluoroacetate

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: [(4R,7aR,12bS)-4a-hydroxy-3-methyl-7-oxo-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl] 2,2,2-trifluoroacetate
• 化学式: C₁₉H₁₆F₃NO₅
• 分子量: 395.3
• InChiKey: WFEBBOURPSGSAH-RSOGGOAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] PROCESS FOR IMPROVED OXYMORPHONE SYNTHESIS<br/>[FR] PROCÉDÉ POUR UNE MEILLEURE SYNTHÈSE DE L'OXYMORPHONE
  申请人：RHODES TECHNOLOGIES

  公开号：WO2015107472A1

  公开（公告）日：2015-07-23

  Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.

  提供了制备氧吗啡的工艺。该工艺包括在三氟乙酸和/或乙二醇存在下对14-羟基吗啡酮盐进行氢化的步骤。
• PROCESS FOR IMPROVED OXYMORPHONE SYNTHESIS
  申请人：RHODES TECHNOLOGIES

  公开号：US20170022209A1

  公开（公告）日：2017-01-26

  Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.

  提供制备氧吗啡的工艺。该工艺包括一步，在三氟乙酸和/或一种二元醇的存在下对14-羟基吗啡酮盐进行氢化的步骤。
• [EN] PROCESS FOR IMPROVED OPIOID SYNTHESIS<br/>[FR] PROCÉDÉ POUR LA SYNTHÈSE AMÉLIORÉE D'OPIOÏDES
  申请人：RHODES TECHNOLOGIES

  公开号：WO2014013313A1

  公开（公告）日：2014-01-23

  Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxymorphone base and/or an oxymorphone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.

  用作制备阿片类药物的起始物质或中间物质的化合物和组合物，例如氧吗啡基和/或氧吗啡盐; 制备这些化合物和组合物的过程; 在制备API和制药剂量形式中使用这些化合物和组合物的用途; 以及在治疗医疗状况中使用所述API和制药剂量形式的用途。
• PROCESS FOR IMPROVED OPIOID SYNTHESIS
  申请人：RHODES TECHNOLOGIES

  公开号：US20150315203A1

  公开（公告）日：2015-11-05

  Compounds and compositions for use as starting materials or intermediate materials in the preparation of opioids including, e.g., oxymorphone base and/or an oxymorphone salt; processes for preparing these compounds and compositions; uses of these compounds and compositions in the preparation of APIs and pharmaceutical dosage forms; and uses of said APIs and pharmaceutical dosage forms in the treatment of medical conditions.

  化合物和组合物可用作制备阿片类药物的起始物质或中间物质，例如氧吗啡基和/或氧吗啡盐；制备这些化合物和组合物的过程；这些化合物和组合物在制备API和制药剂量形式中的用途；以及所述API和制药剂量形式在治疗医疗状况中的用途。
• Process for improved oxymorphone synthesis
  申请人：RHODES TECHNOLOGIES

  公开号：US10189852B2

  公开（公告）日：2019-01-29

  Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.

  提供了制备羟吗啡酮的工艺。所述工艺包括一个步骤，即在三氟乙酸和/或乙二醇存在下对 14-羟基吗啡酮盐进行氢化。