1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)-methyl)-3-cyclopropyl-4-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-benzo[d]imidazol-2-yl)-methyl)-3-cyclopropyl-4-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one
• 英文别名: 1-[[5-Chloro-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-3-cyclopropyl-4-(trifluoromethyl)benzimidazol-2-one；1-[[5-chloro-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-3-cyclopropyl-4-(trifluoromethyl)benzimidazol-2-one
• 化学式: C₂₃H₂₂ClF₃N₄O₃S
• 分子量: 526.967
• InChiKey: RVRMYFUSMWBHHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  83.9
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] COMBINATION THERAPY FOR TREATING A PARAMYXOVIRUS<br/>[FR] POLYTHÉRAPIE POUR TRAITER UN PARAMYXOVIRUS
  申请人：ALIOS BIOPHARMA INC

  公开号：WO2016022464A1

  公开（公告）日：2016-02-11

  Disclosed herein are a combination of compounds and methods of using the combination compounds for ameliorating, treating and/or preventing a paramyxovirus viral infection.

  本文披露了一种化合物组合以及使用该化合物组合来改善、治疗和/或预防副黏病毒感染的方法。
• [EN] 4 - SUBSTITUTED 1, 3 - DIHYDRO - 2H - BENZIMIDAZOL - 2 - ONE DERIVATIVES SUBSTITUTED WITH BENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS<br/>[FR] DÉRIVÉS DE 1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE SUBSTITUÉS EN POSITION 4 PAR DES BENZIMIDAZOLES UTILISÉS COMME AGENTS ANTIVIRAUX CONTRE LE VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：JANSSEN R & D IRELAND

  公开号：WO2013186332A1

  公开（公告）日：2013-12-19

  The present invention is concerned with novel 4-substituted 1,3-dihydro-2H- benzimidazol-2-one derivatives substituted with benzimidazoles having formula (I), tautomers and stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R4, R5, Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

  本发明涉及具有式（I）的苯并咪唑基取代的新型4-取代的1,3-二氢-2H-苯并咪唑-2-酮衍生物，其异构体和立体异构体形式，以及其药学上可接受的加合物和溶剂合物，其中R4、R5、Z和Het在权利要求中定义了含义。根据本发明的化合物可用作对呼吸道合胞病毒（RSV）复制的抑制剂。本发明还涉及制备这种新型化合物，包含这些化合物的组合物，以及用于治疗呼吸道合胞病毒感染的化合物。
• NOVEL 4-SUBSTITUTED 1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES SUBSTITUTED WITH BENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS
  申请人：Janssen R&D Ireland

  公开号：US20150175608A1

  公开（公告）日：2015-06-25

  The present invention is concerned with novel 4-substituted 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with benzimidazoles having formula (I) tautomers and stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R 4 , R 5 , Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

  本发明涉及具有式(I)的苯并咪唑取代基的新型4-取代1,3-二氢-2H-苯并咪唑-2-酮衍生物的构象异构体和立体异构体形式，以及药学上可接受的加合物和其溶剂化物，其中R4、R5、Z和Het在权利要求中有定义。本发明的化合物可用作呼吸道合胞病毒(RSV)复制的抑制剂。本发明还涉及制备这种新型化合物、包含这些化合物的组合物以及用于治疗呼吸道合胞病毒感染的化合物。
• 4 - SUBSTITUTED 1, 3 - DIHYDRO - 2H - BENZIMIDAZOL - 2 - ONE DERIVATIVES SUBSTITUTED WITH BENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS
  申请人：Janssen Sciences Ireland UC

  公开号：EP2864299A1

  公开（公告）日：2015-04-29
• COMBINATION THERAPY FOR TREATING A PARAMYXOVIRUS
  申请人：ALIOS BIOPHARMA, INC.

  公开号：US20160045528A1

  公开（公告）日：2016-02-18

  Disclosed herein are a combination of compounds and methods of using the combination of compounds for ameliorating, treating and/or preventing a paramyxovirus viral infection.