(3-hydroxy-2-oxo-3-phenylpropyl) (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate | 1191924-86-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-hydroxy-2-oxo-3-phenylpropyl) (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
• CAS: 1191924-86-3
• 化学式: C₁₉H₁₇F₃O₅
• 分子量: 382.336
• InChiKey: HNJJODUPUSRTGN-UHUGOGIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,3-二羟基-1-苯基丙烷-2-酮 、 甲氧基-三氟甲基苯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以61%的产率得到(3-hydroxy-2-oxo-3-phenylpropyl) (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
  参考文献：
  名称：

  Application of a modified Mosher’s method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones

  摘要：

  The enantiomeric ratio and absolute configuration of products of the transketolase reaction are typically determined by comparison of the specific rotation or derivatisation and HPLC or GC. A Mosher's ester method has been developed via ester formation at the primary alcohol C-1 which can be used to determine the stereoselectivity of the reaction, as well as the absolute configuration of the product at C-3. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.07.023

文献信息

• Application of a modified Mosher’s method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones
  作者：James L. Galman、Helen C. Hailes

  DOI：10.1016/j.tetasy.2009.07.023

  日期：2009.8

  The enantiomeric ratio and absolute configuration of products of the transketolase reaction are typically determined by comparison of the specific rotation or derivatisation and HPLC or GC. A Mosher's ester method has been developed via ester formation at the primary alcohol C-1 which can be used to determine the stereoselectivity of the reaction, as well as the absolute configuration of the product at C-3. (c) 2009 Elsevier Ltd. All rights reserved.