2-(2-Bromophenyl)-1,3-diphenylguanidine | 913292-35-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-Bromophenyl)-1,3-diphenylguanidine
• 英文别名: 2-(2-bromophenyl)-1,3-diphenylguanidine
• CAS: 913292-35-0
• 化学式: C₁₉H₁₆BrN₃
• 分子量: 366.26
• InChiKey: AHEPEXQLXVMOFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  36.4
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(2-bromophenyl) carbonimidoyl dichloride 、 苯胺 在 caesium carbonate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 1.0h， 以76%的产率得到2-bromo-N-((phenylimino)methylene)aniline
  参考文献：
  名称：

  Copper-catalyzed synthesis of 2-aminobenzimidazoles from carbonimidoyl dichlorides and amines

  摘要：

  A new protocol for the synthesis of a variety of 2-aminobenzimidazole derivatives has been developed. O-haloaryl carbonimidoyl dichloride reacted with anilines to generate an o-haloaryl guanidine intermediate, which underwent copper catalyzed ring closure to afford 2-aminobenzimidazole derivative in moderate yields (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.072

文献信息

• Copper-catalyzed synthesis of 2-aminobenzimidazoles from carbonimidoyl dichlorides and amines
  作者：Hui Yu、Qiong Liu、Yuzhe Li、Chongzhi Ni

  DOI：10.1016/j.tetlet.2012.07.072

  日期：2012.9

  A new protocol for the synthesis of a variety of 2-aminobenzimidazole derivatives has been developed. O-haloaryl carbonimidoyl dichloride reacted with anilines to generate an o-haloaryl guanidine intermediate, which underwent copper catalyzed ring closure to afford 2-aminobenzimidazole derivative in moderate yields (c) 2012 Elsevier Ltd. All rights reserved.